Cargando…

Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells

Ovarian cancer (OC) is one of the most common gynecologic neoplasia and has the highest mortality rate, which is mainly due to late-stage diagnosis and chemotherapy resistance. There is an urgent need to explore new and better therapeutic strategies. We have previously described a family of Microtub...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ovejero-Sánchez, María, Asensio-Juárez, Gloria, González, Myriam, Puebla, Pilar, Vicente-Manzanares, Miguel, Pélaez, Rafael, González-Sarmiento, Rogelio, Herrero, Ana Belén
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657298/ https://www.ncbi.nlm.nih.gov/pubmed/36361809 http://dx.doi.org/10.3390/ijms232113019

Ejemplares similares

Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy
por: González, Myriam, et al.
Publicado: (2021)

Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair
por: Ovejero-Sánchez, María, et al.
Publicado: (2021)

Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line
por: González, Myriam, et al.
Publicado: (2021)

DNA Damage Response Alterations in Ovarian Cancer: From Molecular Mechanisms to Therapeutic Opportunities
por: Ovejero-Sánchez, María, et al.
Publicado: (2023)

Chloroquine-Induced DNA Damage Synergizes with Nonhomologous End Joining Inhibition to Cause Ovarian Cancer Cell Cytotoxicity
por: Ovejero-Sánchez, María, et al.
Publicado: (2022)

Panobinostat Synergistically Enhances the Cytotoxic Effects of Cisplatin, Doxorubicin or Etoposide on High-Risk Neuroblastoma Cells
por: Wang, Guan, et al.
Publicado: (2013)

Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells
por: Asensio-Juárez, Gloria, et al.
Publicado: (2020)

Combination of panobinostat with ponatinib synergistically overcomes imatinib‐resistant CML cells
por: Matsuda, Yasufumi, et al.
Publicado: (2016)

Ectopic A-lattice seams destabilize microtubules
por: Katsuki, Miho, et al.
Publicado: (2014)

TBA-7 is not a microtubule-destabilizing tubulin
por: Lu, Yu-Ming, et al.
Publicado: (2021)

Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death
por: Miller, Nichole M., et al.
Publicado: (2013)

Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat
por: Afolabi, Lukman O., et al.
Publicado: (2021)

Microtubule dissassembly in vivo: intercalary destabilization and breakdown of microtubules in the heliozoan Actinocoryne contractilis
Publicado: (1992)

Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization
por: Fischer, Carina, et al.
Publicado: (2015)

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent
por: Jost, Marco, et al.
Publicado: (2020)

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
por: Hernández-Tiedra, Sonia, et al.
Publicado: (2016)

Panobinostat and Multiple Myeloma in 2018
por: Yee, Andrew J., et al.
Publicado: (2018)

LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation
por: Mian, Isma, et al.
Publicado: (2012)

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
por: Waight, Andrew B., et al.
Publicado: (2016)

Characterization of Microtubule Destabilizing Drugs: A Quantitative Cell-Based Assay That Bridges the Gap between Tubulin Based- and Cytotoxicity Assays
por: Laisne, Marie-Catherine, et al.
Publicado: (2021)

Efficacy of Panobinostat for the Treatment of Multiple Myeloma
por: Eleutherakis-Papaiakovou, Evangelos, et al.
Publicado: (2020)

Importin α/β promote Kif18B microtubule association and enhance microtubule destabilization activity
por: Shrestha, Sanjay, et al.
Publicado: (2023)

Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient Fibroblasts
por: Cartelli, Daniele, et al.
Publicado: (2012)

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
por: Yang, Jianhong, et al.
Publicado: (2016)

HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB
por: Tan, Hao, et al.
Publicado: (2017)

Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK1/2
por: Gao, Lu, et al.
Publicado: (2015)

Panobinostat mediated cell death: a novel therapeutic approach for osteosarcoma
por: Wirries, André, et al.
Publicado: (2018)

Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors
por: Bat-Erdene, Ariunzaya, et al.
Publicado: (2016)

Panobinostat for the treatment of multiple myeloma: the evidence to date
por: Bailey, Hanna, et al.
Publicado: (2015)

A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes
por: Zou, Jianwei, et al.
Publicado: (2008)

Correction: Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient Fibroblasts
por: Cartelli, Daniele, et al.
Publicado: (2012)

Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes
por: Valencia, Rocio G., et al.
Publicado: (2013)

Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization
por: Choi, Bo-Hwa, et al.
Publicado: (2014)

Stu2 acts as a microtubule destabilizer in metaphase budding yeast spindles
por: Humphrey, Lauren, et al.
Publicado: (2018)

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin
por: Sharma, Ashwani, et al.
Publicado: (2017)

Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules
por: Stoiber, Patrick, et al.
Publicado: (2021)

Evaluation of the cytotoxic and immunogenic potential of temozolamide, panobinostat, and Lophophora williamsii extract against C6 glioma cells
por: Franco-Molina, Moisés Armides, et al.
Publicado: (2021)

Correction: Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization
por: Choi, Bo-Hwa, et al.
Publicado: (2018)

Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells
por: Roncato, Francesco, et al.
Publicado: (2021)

Multimodal 4-arylchromene derivatives with microtubule-destabilizing, anti-angiogenic, and MYB-inhibitory activities
por: Köhler, Leonhard H. F., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vmuq31n8mph1odnnvbcvjkdi54