Squaramide-Catalyzed Asymmetric Mannich Reaction between 1,3-Dicarbonyl Compounds and Pyrazolinone Ketimines: A Pathway to Enantioenriched 4-Pyrazolyl- and 4-Isoxazolyl-4-aminopyrazolone Derivatives

A series of N-Boc ketimines derived from pyrazolin-5-ones have been used as electrophiles in enantioselective Mannich reactions with different 1,3-dicarbonyl compounds. This method provides a direct pathway to access the 4-amino-5-pyrazolone derivatives bearing a quaternary substituted stereocenter...

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Detalles Bibliográficos
Autores principales: Gil-Ordóñez, Marta, Aubry, Camille, Niño, Cristopher, Maestro, Alicia, Andrés, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657449/
https://www.ncbi.nlm.nih.gov/pubmed/36296577
http://dx.doi.org/10.3390/molecules27206983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657449/
https://www.ncbi.nlm.nih.gov/pubmed/36296577
http://dx.doi.org/10.3390/molecules27206983

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