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On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhib...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657501/ https://www.ncbi.nlm.nih.gov/pubmed/36362785 http://dx.doi.org/10.3390/jcm11216557 |
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author | Ghin, Filippo Beste, Christian Stock, Ann-Kathrin |
author_facet | Ghin, Filippo Beste, Christian Stock, Ann-Kathrin |
author_sort | Ghin, Filippo |
collection | PubMed |
description | The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhibition in participants with mild-to-moderate AUD and matched healthy controls. For this, a Simon Nogo task was combined with EEG signal decomposition, multivariate pattern analysis (MVPA), and source localization methods. The final sample comprised n = 59 (32♂) AUD participants and n = 64 (28♂) control participants. Compared with the control group, AUD participants showed overall better response inhibition performance. Furthermore, the AUD group was less influenced by the modulatory effect of automatic vs. controlled processes during response inhibition (i.e., had a smaller Simon Nogo effect). The neurophysiological data revealed that the reduced Simon Nogo effect in the AUD group was associated with reduced activation differences between congruent and incongruent Nogo trials in the inferior and middle frontal gyrus. Notably, the drinking frequency (but not the number of AUD criteria we had used to distinguish groups) predicted the extent of the Simon Nogo effect. We suggest that the counterintuitive advantage of participants with mild-to-moderate AUD over those in the control group could be explained by the allostatic model of drinking effects. |
format | Online Article Text |
id | pubmed-9657501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96575012022-11-15 On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder Ghin, Filippo Beste, Christian Stock, Ann-Kathrin J Clin Med Article The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhibition in participants with mild-to-moderate AUD and matched healthy controls. For this, a Simon Nogo task was combined with EEG signal decomposition, multivariate pattern analysis (MVPA), and source localization methods. The final sample comprised n = 59 (32♂) AUD participants and n = 64 (28♂) control participants. Compared with the control group, AUD participants showed overall better response inhibition performance. Furthermore, the AUD group was less influenced by the modulatory effect of automatic vs. controlled processes during response inhibition (i.e., had a smaller Simon Nogo effect). The neurophysiological data revealed that the reduced Simon Nogo effect in the AUD group was associated with reduced activation differences between congruent and incongruent Nogo trials in the inferior and middle frontal gyrus. Notably, the drinking frequency (but not the number of AUD criteria we had used to distinguish groups) predicted the extent of the Simon Nogo effect. We suggest that the counterintuitive advantage of participants with mild-to-moderate AUD over those in the control group could be explained by the allostatic model of drinking effects. MDPI 2022-11-04 /pmc/articles/PMC9657501/ /pubmed/36362785 http://dx.doi.org/10.3390/jcm11216557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ghin, Filippo Beste, Christian Stock, Ann-Kathrin On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder |
title | On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder |
title_full | On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder |
title_fullStr | On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder |
title_full_unstemmed | On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder |
title_short | On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder |
title_sort | on the role of stimulus-response context in inhibitory control in alcohol use disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657501/ https://www.ncbi.nlm.nih.gov/pubmed/36362785 http://dx.doi.org/10.3390/jcm11216557 |
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