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On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder

The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhib...

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Autores principales: Ghin, Filippo, Beste, Christian, Stock, Ann-Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657501/
https://www.ncbi.nlm.nih.gov/pubmed/36362785
http://dx.doi.org/10.3390/jcm11216557
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author Ghin, Filippo
Beste, Christian
Stock, Ann-Kathrin
author_facet Ghin, Filippo
Beste, Christian
Stock, Ann-Kathrin
author_sort Ghin, Filippo
collection PubMed
description The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhibition in participants with mild-to-moderate AUD and matched healthy controls. For this, a Simon Nogo task was combined with EEG signal decomposition, multivariate pattern analysis (MVPA), and source localization methods. The final sample comprised n = 59 (32♂) AUD participants and n = 64 (28♂) control participants. Compared with the control group, AUD participants showed overall better response inhibition performance. Furthermore, the AUD group was less influenced by the modulatory effect of automatic vs. controlled processes during response inhibition (i.e., had a smaller Simon Nogo effect). The neurophysiological data revealed that the reduced Simon Nogo effect in the AUD group was associated with reduced activation differences between congruent and incongruent Nogo trials in the inferior and middle frontal gyrus. Notably, the drinking frequency (but not the number of AUD criteria we had used to distinguish groups) predicted the extent of the Simon Nogo effect. We suggest that the counterintuitive advantage of participants with mild-to-moderate AUD over those in the control group could be explained by the allostatic model of drinking effects.
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spelling pubmed-96575012022-11-15 On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder Ghin, Filippo Beste, Christian Stock, Ann-Kathrin J Clin Med Article The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhibition in participants with mild-to-moderate AUD and matched healthy controls. For this, a Simon Nogo task was combined with EEG signal decomposition, multivariate pattern analysis (MVPA), and source localization methods. The final sample comprised n = 59 (32♂) AUD participants and n = 64 (28♂) control participants. Compared with the control group, AUD participants showed overall better response inhibition performance. Furthermore, the AUD group was less influenced by the modulatory effect of automatic vs. controlled processes during response inhibition (i.e., had a smaller Simon Nogo effect). The neurophysiological data revealed that the reduced Simon Nogo effect in the AUD group was associated with reduced activation differences between congruent and incongruent Nogo trials in the inferior and middle frontal gyrus. Notably, the drinking frequency (but not the number of AUD criteria we had used to distinguish groups) predicted the extent of the Simon Nogo effect. We suggest that the counterintuitive advantage of participants with mild-to-moderate AUD over those in the control group could be explained by the allostatic model of drinking effects. MDPI 2022-11-04 /pmc/articles/PMC9657501/ /pubmed/36362785 http://dx.doi.org/10.3390/jcm11216557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ghin, Filippo
Beste, Christian
Stock, Ann-Kathrin
On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
title On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
title_full On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
title_fullStr On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
title_full_unstemmed On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
title_short On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder
title_sort on the role of stimulus-response context in inhibitory control in alcohol use disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657501/
https://www.ncbi.nlm.nih.gov/pubmed/36362785
http://dx.doi.org/10.3390/jcm11216557
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