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A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss

Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the...

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Detalles Bibliográficos
Autores principales: Chin, Kok-Yong, Ng, Ben Nett, Rostam, Muhd Khairik Imran, Muhammad Fadzil, Nur Farah Dhaniyah, Raman, Vaishnavi, Mohamed Yunus, Farzana, Syed Hashim, Syed Alhafiz, Ekeuku, Sophia Ogechi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657533/
https://www.ncbi.nlm.nih.gov/pubmed/36362662
http://dx.doi.org/10.3390/jcm11216434
Descripción
Sumario:Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the physiological bone remodelling to a more catabolic process that results in net bone loss. This review aims to provide an overview of osteoporosis from its biology, epidemiology and clinical aspects (detection and pharmacological management). The review will serve as an updated reference for readers to understand the basics of osteoporosis and take action to prevent and manage this disease.