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A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657533/ https://www.ncbi.nlm.nih.gov/pubmed/36362662 http://dx.doi.org/10.3390/jcm11216434 |
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author | Chin, Kok-Yong Ng, Ben Nett Rostam, Muhd Khairik Imran Muhammad Fadzil, Nur Farah Dhaniyah Raman, Vaishnavi Mohamed Yunus, Farzana Syed Hashim, Syed Alhafiz Ekeuku, Sophia Ogechi |
author_facet | Chin, Kok-Yong Ng, Ben Nett Rostam, Muhd Khairik Imran Muhammad Fadzil, Nur Farah Dhaniyah Raman, Vaishnavi Mohamed Yunus, Farzana Syed Hashim, Syed Alhafiz Ekeuku, Sophia Ogechi |
author_sort | Chin, Kok-Yong |
collection | PubMed |
description | Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the physiological bone remodelling to a more catabolic process that results in net bone loss. This review aims to provide an overview of osteoporosis from its biology, epidemiology and clinical aspects (detection and pharmacological management). The review will serve as an updated reference for readers to understand the basics of osteoporosis and take action to prevent and manage this disease. |
format | Online Article Text |
id | pubmed-9657533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96575332022-11-15 A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss Chin, Kok-Yong Ng, Ben Nett Rostam, Muhd Khairik Imran Muhammad Fadzil, Nur Farah Dhaniyah Raman, Vaishnavi Mohamed Yunus, Farzana Syed Hashim, Syed Alhafiz Ekeuku, Sophia Ogechi J Clin Med Review Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the physiological bone remodelling to a more catabolic process that results in net bone loss. This review aims to provide an overview of osteoporosis from its biology, epidemiology and clinical aspects (detection and pharmacological management). The review will serve as an updated reference for readers to understand the basics of osteoporosis and take action to prevent and manage this disease. MDPI 2022-10-30 /pmc/articles/PMC9657533/ /pubmed/36362662 http://dx.doi.org/10.3390/jcm11216434 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chin, Kok-Yong Ng, Ben Nett Rostam, Muhd Khairik Imran Muhammad Fadzil, Nur Farah Dhaniyah Raman, Vaishnavi Mohamed Yunus, Farzana Syed Hashim, Syed Alhafiz Ekeuku, Sophia Ogechi A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss |
title | A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss |
title_full | A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss |
title_fullStr | A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss |
title_full_unstemmed | A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss |
title_short | A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss |
title_sort | mini review on osteoporosis: from biology to pharmacological management of bone loss |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657533/ https://www.ncbi.nlm.nih.gov/pubmed/36362662 http://dx.doi.org/10.3390/jcm11216434 |
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