Cargando…

Changes in Acute Phase Response Biomarkers in Racing Endurance Horses

SIMPLE SUMMARY: Sport horses competing in exhausting sporting events require special attention to ensure their welfare. Changes in acute phase response induced by both aerobic and anaerobic exercise are studied for understanding the physiological response to strenuous exercise. We suggest that endur...

Descripción completa

Detalles Bibliográficos
Autores principales: Mihelić, Karla, Vrbanac, Zoran, Bojanić, Krunoslav, Kostanjšak, Tara, Ljubić, Blanka Beer, Gotić, Jelena, Vnuk, Dražen, Bottegaro, Nika Brkljača
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657625/
https://www.ncbi.nlm.nih.gov/pubmed/36359117
http://dx.doi.org/10.3390/ani12212993
_version_ 1784829744302260224
author Mihelić, Karla
Vrbanac, Zoran
Bojanić, Krunoslav
Kostanjšak, Tara
Ljubić, Blanka Beer
Gotić, Jelena
Vnuk, Dražen
Bottegaro, Nika Brkljača
author_facet Mihelić, Karla
Vrbanac, Zoran
Bojanić, Krunoslav
Kostanjšak, Tara
Ljubić, Blanka Beer
Gotić, Jelena
Vnuk, Dražen
Bottegaro, Nika Brkljača
author_sort Mihelić, Karla
collection PubMed
description SIMPLE SUMMARY: Sport horses competing in exhausting sporting events require special attention to ensure their welfare. Changes in acute phase response induced by both aerobic and anaerobic exercise are studied for understanding the physiological response to strenuous exercise. We suggest that endurance racing induces acute phase response in horses, characterized by a decrease in calprotectin and haptoglobin values, and an increase in concentrations of ceruloplasmin and albumin, with more pronounced changes noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races. ABSTRACT: This study aimed to evaluate if exercise-induced acute phase response (APR) occurs in endurance horses in response to the race. The study included 23 horses competing in an endurance competition with a successfully passed clinical examination before the race. Blood samples were collected before the start and within 30 min after the end of the race. Haematological and biochemical tests were performed and correlated to acute phase biomarkers changes. Values of calprotectin and haptoglobin (Hp) decreased after the races compared to values before, while concentrations of ceruloplasmin and albumin recorded a significant increase. Greater changes in calprotectin values were noted in Arabian horses compared to other breeds. Values of Hp showed a significantly greater decrease after longer races. Based on study results, endurance racing induces APR in horses characterised by significant changes in selected acute phase biomarkers. More pronounced changes were noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races.
format Online
Article
Text
id pubmed-9657625
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96576252022-11-15 Changes in Acute Phase Response Biomarkers in Racing Endurance Horses Mihelić, Karla Vrbanac, Zoran Bojanić, Krunoslav Kostanjšak, Tara Ljubić, Blanka Beer Gotić, Jelena Vnuk, Dražen Bottegaro, Nika Brkljača Animals (Basel) Article SIMPLE SUMMARY: Sport horses competing in exhausting sporting events require special attention to ensure their welfare. Changes in acute phase response induced by both aerobic and anaerobic exercise are studied for understanding the physiological response to strenuous exercise. We suggest that endurance racing induces acute phase response in horses, characterized by a decrease in calprotectin and haptoglobin values, and an increase in concentrations of ceruloplasmin and albumin, with more pronounced changes noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races. ABSTRACT: This study aimed to evaluate if exercise-induced acute phase response (APR) occurs in endurance horses in response to the race. The study included 23 horses competing in an endurance competition with a successfully passed clinical examination before the race. Blood samples were collected before the start and within 30 min after the end of the race. Haematological and biochemical tests were performed and correlated to acute phase biomarkers changes. Values of calprotectin and haptoglobin (Hp) decreased after the races compared to values before, while concentrations of ceruloplasmin and albumin recorded a significant increase. Greater changes in calprotectin values were noted in Arabian horses compared to other breeds. Values of Hp showed a significantly greater decrease after longer races. Based on study results, endurance racing induces APR in horses characterised by significant changes in selected acute phase biomarkers. More pronounced changes were noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races. MDPI 2022-10-31 /pmc/articles/PMC9657625/ /pubmed/36359117 http://dx.doi.org/10.3390/ani12212993 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mihelić, Karla
Vrbanac, Zoran
Bojanić, Krunoslav
Kostanjšak, Tara
Ljubić, Blanka Beer
Gotić, Jelena
Vnuk, Dražen
Bottegaro, Nika Brkljača
Changes in Acute Phase Response Biomarkers in Racing Endurance Horses
title Changes in Acute Phase Response Biomarkers in Racing Endurance Horses
title_full Changes in Acute Phase Response Biomarkers in Racing Endurance Horses
title_fullStr Changes in Acute Phase Response Biomarkers in Racing Endurance Horses
title_full_unstemmed Changes in Acute Phase Response Biomarkers in Racing Endurance Horses
title_short Changes in Acute Phase Response Biomarkers in Racing Endurance Horses
title_sort changes in acute phase response biomarkers in racing endurance horses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657625/
https://www.ncbi.nlm.nih.gov/pubmed/36359117
http://dx.doi.org/10.3390/ani12212993
work_keys_str_mv AT mihelickarla changesinacutephaseresponsebiomarkersinracingendurancehorses
AT vrbanaczoran changesinacutephaseresponsebiomarkersinracingendurancehorses
AT bojanickrunoslav changesinacutephaseresponsebiomarkersinracingendurancehorses
AT kostanjsaktara changesinacutephaseresponsebiomarkersinracingendurancehorses
AT ljubicblankabeer changesinacutephaseresponsebiomarkersinracingendurancehorses
AT goticjelena changesinacutephaseresponsebiomarkersinracingendurancehorses
AT vnukdrazen changesinacutephaseresponsebiomarkersinracingendurancehorses
AT bottegaronikabrkljaca changesinacutephaseresponsebiomarkersinracingendurancehorses