Cargando…
Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry)
The impact of diabetes mellitus (DM) on outcomes of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was confirmed by several studies. However, it is unclear whether this effect is still present in large groups of unselected...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657628/ https://www.ncbi.nlm.nih.gov/pubmed/36362512 http://dx.doi.org/10.3390/jcm11216284 |
_version_ | 1784829744990126080 |
---|---|
author | Dziewierz, Artur Zdzierak, Barbara Malinowski, Krzysztof P. Siudak, Zbigniew Zasada, Wojciech Tokarek, Tomasz Zabojszcz, Michał Dolecka-Ślusarczyk, Magdalena Dudek, Dariusz Bartuś, Stanisław Surdacki, Andrzej Rakowski, Tomasz |
author_facet | Dziewierz, Artur Zdzierak, Barbara Malinowski, Krzysztof P. Siudak, Zbigniew Zasada, Wojciech Tokarek, Tomasz Zabojszcz, Michał Dolecka-Ślusarczyk, Magdalena Dudek, Dariusz Bartuś, Stanisław Surdacki, Andrzej Rakowski, Tomasz |
author_sort | Dziewierz, Artur |
collection | PubMed |
description | The impact of diabetes mellitus (DM) on outcomes of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was confirmed by several studies. However, it is unclear whether this effect is still present in large groups of unselected patients undergoing up-to-date treatment. Thus, we sought to assess the impact of DM on periprocedural outcomes of primary PCI in STEMI using data from the Polish National Registry of PCI. Data on 150,782 STEMI patients undergoing primary PCI were collected. Of them, 26,360 (17.5%) patients had DM. Patients with DM were higher-risk individuals who experienced longer reperfusion delays and were less likely to have closed infarct-related artery at baseline (TIMI 0 + 1 flow: 73.2% vs. 72.0%; p < 0.0001) and achieve optimal reperfusion after PCI (TIMI 3 flow: 91.8% vs. 88.5%; p < 0.0001). The periprocedural mortality (1.1% vs. 1.9%; p < 0.0001) was higher in patients with DM and DM was identified as an independent predictor of periprocedural death. In conclusion, despite continuous progress in STEMI treatment, DM remains a strong predictor of periprocedural mortality. However, this detrimental effect of DM may be partially explained by the overall higher risk profile of diabetic patients. |
format | Online Article Text |
id | pubmed-9657628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96576282022-11-15 Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) Dziewierz, Artur Zdzierak, Barbara Malinowski, Krzysztof P. Siudak, Zbigniew Zasada, Wojciech Tokarek, Tomasz Zabojszcz, Michał Dolecka-Ślusarczyk, Magdalena Dudek, Dariusz Bartuś, Stanisław Surdacki, Andrzej Rakowski, Tomasz J Clin Med Article The impact of diabetes mellitus (DM) on outcomes of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was confirmed by several studies. However, it is unclear whether this effect is still present in large groups of unselected patients undergoing up-to-date treatment. Thus, we sought to assess the impact of DM on periprocedural outcomes of primary PCI in STEMI using data from the Polish National Registry of PCI. Data on 150,782 STEMI patients undergoing primary PCI were collected. Of them, 26,360 (17.5%) patients had DM. Patients with DM were higher-risk individuals who experienced longer reperfusion delays and were less likely to have closed infarct-related artery at baseline (TIMI 0 + 1 flow: 73.2% vs. 72.0%; p < 0.0001) and achieve optimal reperfusion after PCI (TIMI 3 flow: 91.8% vs. 88.5%; p < 0.0001). The periprocedural mortality (1.1% vs. 1.9%; p < 0.0001) was higher in patients with DM and DM was identified as an independent predictor of periprocedural death. In conclusion, despite continuous progress in STEMI treatment, DM remains a strong predictor of periprocedural mortality. However, this detrimental effect of DM may be partially explained by the overall higher risk profile of diabetic patients. MDPI 2022-10-25 /pmc/articles/PMC9657628/ /pubmed/36362512 http://dx.doi.org/10.3390/jcm11216284 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dziewierz, Artur Zdzierak, Barbara Malinowski, Krzysztof P. Siudak, Zbigniew Zasada, Wojciech Tokarek, Tomasz Zabojszcz, Michał Dolecka-Ślusarczyk, Magdalena Dudek, Dariusz Bartuś, Stanisław Surdacki, Andrzej Rakowski, Tomasz Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) |
title | Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) |
title_full | Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) |
title_fullStr | Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) |
title_full_unstemmed | Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) |
title_short | Diabetes Mellitus Is Still a Strong Predictor of Periprocedural Outcomes of Primary Percutaneous Coronary Interventions in Patients Presenting with ST-Segment Elevation Myocardial Infarction (from the ORPKI Polish National Registry) |
title_sort | diabetes mellitus is still a strong predictor of periprocedural outcomes of primary percutaneous coronary interventions in patients presenting with st-segment elevation myocardial infarction (from the orpki polish national registry) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657628/ https://www.ncbi.nlm.nih.gov/pubmed/36362512 http://dx.doi.org/10.3390/jcm11216284 |
work_keys_str_mv | AT dziewierzartur diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT zdzierakbarbara diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT malinowskikrzysztofp diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT siudakzbigniew diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT zasadawojciech diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT tokarektomasz diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT zabojszczmichał diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT doleckaslusarczykmagdalena diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT dudekdariusz diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT bartusstanisław diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT surdackiandrzej diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry AT rakowskitomasz diabetesmellitusisstillastrongpredictorofperiproceduraloutcomesofprimarypercutaneouscoronaryinterventionsinpatientspresentingwithstsegmentelevationmyocardialinfarctionfromtheorpkipolishnationalregistry |