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Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review

Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal host–microbe homeostasis, manifested by the destruction of tooth-supporting structures, especially inflammatory alveolar bone loss. Osteoporosis is characterized by systemic deterioration of bone mass and m...

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Detalles Bibliográficos
Autores principales: Zhu, Li, Zhou, Chenchen, Chen, Shuo, Huang, Danyuan, Jiang, Yukun, Lan, Yuanchen, Zou, Shujuan, Li, Yuyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657655/
https://www.ncbi.nlm.nih.gov/pubmed/36359775
http://dx.doi.org/10.3390/cells11213380
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author Zhu, Li
Zhou, Chenchen
Chen, Shuo
Huang, Danyuan
Jiang, Yukun
Lan, Yuanchen
Zou, Shujuan
Li, Yuyu
author_facet Zhu, Li
Zhou, Chenchen
Chen, Shuo
Huang, Danyuan
Jiang, Yukun
Lan, Yuanchen
Zou, Shujuan
Li, Yuyu
author_sort Zhu, Li
collection PubMed
description Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal host–microbe homeostasis, manifested by the destruction of tooth-supporting structures, especially inflammatory alveolar bone loss. Osteoporosis is characterized by systemic deterioration of bone mass and microarchitecture. The roles of many systemic factors have been identified in the pathogenesis of osteoporosis, including endocrine change, metabolic disorders, health-impaired behaviors and mental stress. The prevalence rate of osteoporotic fracture is in sustained elevation in the past decades. Recent studies suggest that individuals with concomitant osteoporosis are more vulnerable to periodontal impairment. Current reviews of worse periodontal status in the context of osteoporosis are limited, mainly centering on the impacts of menopausal and diabetic osteoporosis on periodontitis. Herein, this review article makes an effort to provide a comprehensive view of the relationship between osteoporosis and periodontitis, with a focus on clarifying how those risk factors in osteoporotic populations modify the alveolar bone homeostasis in the periodontitis niche.
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spelling pubmed-96576552022-11-15 Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review Zhu, Li Zhou, Chenchen Chen, Shuo Huang, Danyuan Jiang, Yukun Lan, Yuanchen Zou, Shujuan Li, Yuyu Cells Review Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal host–microbe homeostasis, manifested by the destruction of tooth-supporting structures, especially inflammatory alveolar bone loss. Osteoporosis is characterized by systemic deterioration of bone mass and microarchitecture. The roles of many systemic factors have been identified in the pathogenesis of osteoporosis, including endocrine change, metabolic disorders, health-impaired behaviors and mental stress. The prevalence rate of osteoporotic fracture is in sustained elevation in the past decades. Recent studies suggest that individuals with concomitant osteoporosis are more vulnerable to periodontal impairment. Current reviews of worse periodontal status in the context of osteoporosis are limited, mainly centering on the impacts of menopausal and diabetic osteoporosis on periodontitis. Herein, this review article makes an effort to provide a comprehensive view of the relationship between osteoporosis and periodontitis, with a focus on clarifying how those risk factors in osteoporotic populations modify the alveolar bone homeostasis in the periodontitis niche. MDPI 2022-10-26 /pmc/articles/PMC9657655/ /pubmed/36359775 http://dx.doi.org/10.3390/cells11213380 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhu, Li
Zhou, Chenchen
Chen, Shuo
Huang, Danyuan
Jiang, Yukun
Lan, Yuanchen
Zou, Shujuan
Li, Yuyu
Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review
title Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review
title_full Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review
title_fullStr Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review
title_full_unstemmed Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review
title_short Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review
title_sort osteoporosis and alveolar bone health in periodontitis niche: a predisposing factors-centered review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657655/
https://www.ncbi.nlm.nih.gov/pubmed/36359775
http://dx.doi.org/10.3390/cells11213380
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