Cargando…

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While gene-wide association studies and next generation sequencing analyses have identified molecular patterns and transcriptome profiles with prog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Giorgio, Cristina, Lupia, Antonio, Marchianò, Silvia, Bordoni, Martina, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Roselli, Rosalinda, Moraca, Federica, Sepe, Valentina, Catalanotti, Bruno, Morretta, Elva, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657739/ https://www.ncbi.nlm.nih.gov/pubmed/36359879 http://dx.doi.org/10.3390/cells11213482

Ejemplares similares

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma
por: Di Giorgio, Cristina, et al.
Publicado: (2023)

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH
por: Marchianò, Silvia, et al.
Publicado: (2023)

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation
por: Carino, Adriana, et al.
Publicado: (2019)

Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis
por: Di Giorgio, Cristina, et al.
Publicado: (2022)

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation
por: Biagioli, Michele, et al.
Publicado: (2022)

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT(1)R Modulator for the Treatment of Metabolic Fatty Liver Disease
por: Fiorucci, Stefano, et al.
Publicado: (2022)

Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction
por: Biagioli, Michele, et al.
Publicado: (2021)

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain
por: Carino, Adriana, et al.
Publicado: (2020)

Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders
por: Fiorillo, Bianca, et al.
Publicado: (2023)

Correction to “Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders”
por: Fiorillo, Bianca, et al.
Publicado: (2023)

Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation
por: Biagioli, Michele, et al.
Publicado: (2020)

Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics
por: Fiorillo, Bianca, et al.
Publicado: (2021)

GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis
por: Biagioli, Michele, et al.
Publicado: (2019)

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential
por: Carino, Adriana, et al.
Publicado: (2021)

Bile Acids Activated Receptors Regulate Innate Immunity
por: Fiorucci, Stefano, et al.
Publicado: (2018)

The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions
por: Biagioli, Michele, et al.
Publicado: (2019)

Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties
por: Biagioli, Michele, et al.
Publicado: (2019)

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands
por: Finamore, Claudia, et al.
Publicado: (2016)

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice
por: Carino, Adriana, et al.
Publicado: (2017)

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists
por: Finamore, Claudia, et al.
Publicado: (2023)

Bile Acids Activated Receptors in Inflammatory Bowel Disease
por: Biagioli, Michele, et al.
Publicado: (2021)

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases
por: Festa, Carmen, et al.
Publicado: (2017)

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis
por: Carino, Adriana, et al.
Publicado: (2017)

Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma
por: Sagers, Jessica E., et al.
Publicado: (2018)

Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity
por: Biagioli, Michele, et al.
Publicado: (2017)

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties
por: Finamore, Claudia, et al.
Publicado: (2019)

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma
por: Renga, Barbara, et al.
Publicado: (2015)

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones
por: Monticelli, Maria, et al.
Publicado: (2022)

Publisher Correction: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma
por: Sagers, Jessica E., et al.
Publicado: (2018)

Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis
por: Cipriani, Sabrina, et al.
Publicado: (2017)

The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines
por: Carino, Adriana, et al.
Publicado: (2016)

Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis
por: Mencarelli, Andrea, et al.
Publicado: (2013)

Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists
por: De Marino, Simona, et al.
Publicado: (2017)

Bile Acid Signaling in Inflammatory Bowel Diseases
por: Fiorucci, Stefano, et al.
Publicado: (2020)

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches
por: Morretta, Elva, et al.
Publicado: (2017)

Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative
por: Morretta, Elva, et al.
Publicado: (2023)

Transcriptional drug repositioning and cheminformatics approach for differentiation therapy of leukaemia cells
por: KalantarMotamedi, Yasaman, et al.
Publicado: (2021)

Mifepristone-Induced Hypothyroidism
por: Kalara, Niketa, et al.
Publicado: (2023)

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling
por: Cipriani, Sabrina, et al.
Publicado: (2015)

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists
por: Sepe, Valentina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tkji5l2dti4rndd7kuebb4sceo