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Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions

Transcription factors members of the basic leucine zipper (bZIP) class play important roles in the regulation of genes and functions in testicular Leydig cells. Many of these factors, such as cAMP responsive element binding protein 1 (CREB1) and CCAAT enhancer binding protein beta (CEBPB), are regul...

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Autores principales: Martin, Luc J., Nguyen, Ha Tuyen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658026/
https://www.ncbi.nlm.nih.gov/pubmed/36361676
http://dx.doi.org/10.3390/ijms232112887
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author Martin, Luc J.
Nguyen, Ha Tuyen
author_facet Martin, Luc J.
Nguyen, Ha Tuyen
author_sort Martin, Luc J.
collection PubMed
description Transcription factors members of the basic leucine zipper (bZIP) class play important roles in the regulation of genes and functions in testicular Leydig cells. Many of these factors, such as cAMP responsive element binding protein 1 (CREB1) and CCAAT enhancer binding protein beta (CEBPB), are regulated by the cAMP/protein kinase A (PKA) pathway, the main signaling pathway activated following the activation of the luteinizing hormone/choriogonadotropin membrane receptor LHCGR by the - hormone LH. Others, such as X-box binding protein 1 (XBP1) and members of the cAMP responsive element binding protein 3 (CREB3)-like superfamily, are implicated in the endoplasmic reticulum stress by regulating the unfolded protein response. In this review, the influences of bZIP transcription factors, including CREB1, CEBPB and activator protein 1 (AP-1) family members, on the regulation of genes important for cell proliferation, steroidogenesis and Leydig cell communication will be covered. In addition, unresolved questions regarding the mechanisms of actions of bZIP members in gene regulation will be identified.
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spelling pubmed-96580262022-11-15 Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions Martin, Luc J. Nguyen, Ha Tuyen Int J Mol Sci Review Transcription factors members of the basic leucine zipper (bZIP) class play important roles in the regulation of genes and functions in testicular Leydig cells. Many of these factors, such as cAMP responsive element binding protein 1 (CREB1) and CCAAT enhancer binding protein beta (CEBPB), are regulated by the cAMP/protein kinase A (PKA) pathway, the main signaling pathway activated following the activation of the luteinizing hormone/choriogonadotropin membrane receptor LHCGR by the - hormone LH. Others, such as X-box binding protein 1 (XBP1) and members of the cAMP responsive element binding protein 3 (CREB3)-like superfamily, are implicated in the endoplasmic reticulum stress by regulating the unfolded protein response. In this review, the influences of bZIP transcription factors, including CREB1, CEBPB and activator protein 1 (AP-1) family members, on the regulation of genes important for cell proliferation, steroidogenesis and Leydig cell communication will be covered. In addition, unresolved questions regarding the mechanisms of actions of bZIP members in gene regulation will be identified. MDPI 2022-10-25 /pmc/articles/PMC9658026/ /pubmed/36361676 http://dx.doi.org/10.3390/ijms232112887 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martin, Luc J.
Nguyen, Ha Tuyen
Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions
title Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions
title_full Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions
title_fullStr Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions
title_full_unstemmed Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions
title_short Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells’ Functions
title_sort basic leucine zipper transcription factors as important regulators of leydig cells’ functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658026/
https://www.ncbi.nlm.nih.gov/pubmed/36361676
http://dx.doi.org/10.3390/ijms232112887
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