Cargando…
SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease
SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3′ splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have uncovered new and non-redundant roles of SLU7 as an...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658179/ https://www.ncbi.nlm.nih.gov/pubmed/36362191 http://dx.doi.org/10.3390/ijms232113411 |
_version_ | 1784829886480777216 |
---|---|
author | Gárate-Rascón, María Recalde, Miriam Rojo, Carla Fernández-Barrena, Maite G. Ávila, Matías A. Arechederra, María Berasain, Carmen |
author_facet | Gárate-Rascón, María Recalde, Miriam Rojo, Carla Fernández-Barrena, Maite G. Ávila, Matías A. Arechederra, María Berasain, Carmen |
author_sort | Gárate-Rascón, María |
collection | PubMed |
description | SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3′ splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have uncovered new and non-redundant roles of SLU7 as an integrative hub of different levels of gene expression regulation, including epigenetic DNA remodeling, modulation of transcription and protein stability. Here we review those findings, the multiple factors and mechanisms implicated as well as the cellular functions affected. For instance, SLU7 is essential to secure liver differentiation, genome integrity acting at different levels and a correct cell cycle progression. Accordingly, the aberrant expression of SLU7 could be associated with human diseases including cancer, although strikingly, it is an essential survival factor for cancer cells. Finally, we discuss the implications of SLU7 in pathophysiology, with particular emphasis on the progression of liver disease and its possible role as a therapeutic target in human cancer. |
format | Online Article Text |
id | pubmed-9658179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96581792022-11-15 SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease Gárate-Rascón, María Recalde, Miriam Rojo, Carla Fernández-Barrena, Maite G. Ávila, Matías A. Arechederra, María Berasain, Carmen Int J Mol Sci Review SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3′ splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have uncovered new and non-redundant roles of SLU7 as an integrative hub of different levels of gene expression regulation, including epigenetic DNA remodeling, modulation of transcription and protein stability. Here we review those findings, the multiple factors and mechanisms implicated as well as the cellular functions affected. For instance, SLU7 is essential to secure liver differentiation, genome integrity acting at different levels and a correct cell cycle progression. Accordingly, the aberrant expression of SLU7 could be associated with human diseases including cancer, although strikingly, it is an essential survival factor for cancer cells. Finally, we discuss the implications of SLU7 in pathophysiology, with particular emphasis on the progression of liver disease and its possible role as a therapeutic target in human cancer. MDPI 2022-11-02 /pmc/articles/PMC9658179/ /pubmed/36362191 http://dx.doi.org/10.3390/ijms232113411 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gárate-Rascón, María Recalde, Miriam Rojo, Carla Fernández-Barrena, Maite G. Ávila, Matías A. Arechederra, María Berasain, Carmen SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease |
title | SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease |
title_full | SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease |
title_fullStr | SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease |
title_full_unstemmed | SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease |
title_short | SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease |
title_sort | slu7: a new hub of gene expression regulation—from epigenetics to protein stability in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658179/ https://www.ncbi.nlm.nih.gov/pubmed/36362191 http://dx.doi.org/10.3390/ijms232113411 |
work_keys_str_mv | AT garaterasconmaria slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease AT recaldemiriam slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease AT rojocarla slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease AT fernandezbarrenamaiteg slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease AT avilamatiasa slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease AT arechederramaria slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease AT berasaincarmen slu7anewhubofgeneexpressionregulationfromepigeneticstoproteinstabilityinhealthanddisease |