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The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event

β-N-methylamino L-alanine (BMAA) is a neurotoxin linked to high incidences of neurodegenerative disease. The toxin, along with two of its common isomers, 2,4-diaminobuytric acid (2,4-DAB) and N-(2-aminoethyl)glycine (AEG), is produced by multiple genera of cyanobacteria worldwide. Whilst there are m...

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Autores principales: Peters, Siobhan J., Rodgers, Kenneth J., Mitrovic, Simon M., Bishop, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658504/
https://www.ncbi.nlm.nih.gov/pubmed/36364208
http://dx.doi.org/10.3390/molecules27217382
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author Peters, Siobhan J.
Rodgers, Kenneth J.
Mitrovic, Simon M.
Bishop, David P.
author_facet Peters, Siobhan J.
Rodgers, Kenneth J.
Mitrovic, Simon M.
Bishop, David P.
author_sort Peters, Siobhan J.
collection PubMed
description β-N-methylamino L-alanine (BMAA) is a neurotoxin linked to high incidences of neurodegenerative disease. The toxin, along with two of its common isomers, 2,4-diaminobuytric acid (2,4-DAB) and N-(2-aminoethyl)glycine (AEG), is produced by multiple genera of cyanobacteria worldwide. Whilst there are many reports of locations and species of cyanobacteria associated with the production of BMAA during a bloom, there is a lack of information tracking changes in concentration across a single bloom event. This study aimed to measure the concentrations of BMAA and its isomers through the progression and end of a cyanobacteria bloom event using liquid chromatography-triple quadrupole-mass spectrometry. BMAA was detected in all samples analysed, with a decreasing trend observed as the bloom progressed. BMAA’s isomers were also detected in all samples, however, they did not follow the same decreasing pattern. This study highlights the potential for current sampling protocols that measure a single time point as representative of a bloom’s overall toxin content to underestimate BMAA concentration during a bloom event.
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spelling pubmed-96585042022-11-15 The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event Peters, Siobhan J. Rodgers, Kenneth J. Mitrovic, Simon M. Bishop, David P. Molecules Article β-N-methylamino L-alanine (BMAA) is a neurotoxin linked to high incidences of neurodegenerative disease. The toxin, along with two of its common isomers, 2,4-diaminobuytric acid (2,4-DAB) and N-(2-aminoethyl)glycine (AEG), is produced by multiple genera of cyanobacteria worldwide. Whilst there are many reports of locations and species of cyanobacteria associated with the production of BMAA during a bloom, there is a lack of information tracking changes in concentration across a single bloom event. This study aimed to measure the concentrations of BMAA and its isomers through the progression and end of a cyanobacteria bloom event using liquid chromatography-triple quadrupole-mass spectrometry. BMAA was detected in all samples analysed, with a decreasing trend observed as the bloom progressed. BMAA’s isomers were also detected in all samples, however, they did not follow the same decreasing pattern. This study highlights the potential for current sampling protocols that measure a single time point as representative of a bloom’s overall toxin content to underestimate BMAA concentration during a bloom event. MDPI 2022-10-30 /pmc/articles/PMC9658504/ /pubmed/36364208 http://dx.doi.org/10.3390/molecules27217382 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peters, Siobhan J.
Rodgers, Kenneth J.
Mitrovic, Simon M.
Bishop, David P.
The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event
title The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event
title_full The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event
title_fullStr The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event
title_full_unstemmed The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event
title_short The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event
title_sort changes in cyanobacterial concentration of β-methylamino-l-alanine during a bloom event
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658504/
https://www.ncbi.nlm.nih.gov/pubmed/36364208
http://dx.doi.org/10.3390/molecules27217382
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