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Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial

Hemodialysis patients with diabetic kidney disease (DKD) experience blood glucose fluctuations owing to insulin removal. We evaluated the effects of single and long-term application of neuromuscular electrical stimulation (NMES) during hemodialysis on glycemic control. This trial was conducted in tw...

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Autores principales: Tsurumi, Tomoki, Tamura, Yuma, Nakatani, Yuki, Furuya, Tomoki, Tamiya, Hajime, Terashima, Masato, Tomoe, Takashi, Ueno, Asuka, Shimoyama, Masahiro, Yasu, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658571/
https://www.ncbi.nlm.nih.gov/pubmed/36362467
http://dx.doi.org/10.3390/jcm11216239
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author Tsurumi, Tomoki
Tamura, Yuma
Nakatani, Yuki
Furuya, Tomoki
Tamiya, Hajime
Terashima, Masato
Tomoe, Takashi
Ueno, Asuka
Shimoyama, Masahiro
Yasu, Takanori
author_facet Tsurumi, Tomoki
Tamura, Yuma
Nakatani, Yuki
Furuya, Tomoki
Tamiya, Hajime
Terashima, Masato
Tomoe, Takashi
Ueno, Asuka
Shimoyama, Masahiro
Yasu, Takanori
author_sort Tsurumi, Tomoki
collection PubMed
description Hemodialysis patients with diabetic kidney disease (DKD) experience blood glucose fluctuations owing to insulin removal. We evaluated the effects of single and long-term application of neuromuscular electrical stimulation (NMES) during hemodialysis on glycemic control. This trial was conducted in two stages: Stage 1, following a crossover design and 4 week washout period, eleven outpatients with DKD either underwent a single bout of NMES for 30 min (NMES period) or rested (control period) after receiving nutritional support during hemodialysis; Stage 2, following a crossover design and 4 week washout period, each participant received the intervention for 12 weeks. NMES was administered for 30 min at the maximum tolerable intensity. The mean subcutaneous glucose concentration and mean amplitude of glycemic excursion (MAGE) were determined by flash glucose monitoring for 24 h. Changes in glycoalbumin and MAGE before and after NMES initiation were evaluated. The mean blood glucose level and MAGE after a single bout of NMES were significantly lower than those after rest. Glycoalbumin levels and echo intensity of the rectus femoris tended to decrease, but not significantly by ANOVA due to a lack in statistical power after the dropout of three patients. NMES in end-stage DKD decreased blood glucose levels during and after hemodialysis.
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spelling pubmed-96585712022-11-15 Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial Tsurumi, Tomoki Tamura, Yuma Nakatani, Yuki Furuya, Tomoki Tamiya, Hajime Terashima, Masato Tomoe, Takashi Ueno, Asuka Shimoyama, Masahiro Yasu, Takanori J Clin Med Article Hemodialysis patients with diabetic kidney disease (DKD) experience blood glucose fluctuations owing to insulin removal. We evaluated the effects of single and long-term application of neuromuscular electrical stimulation (NMES) during hemodialysis on glycemic control. This trial was conducted in two stages: Stage 1, following a crossover design and 4 week washout period, eleven outpatients with DKD either underwent a single bout of NMES for 30 min (NMES period) or rested (control period) after receiving nutritional support during hemodialysis; Stage 2, following a crossover design and 4 week washout period, each participant received the intervention for 12 weeks. NMES was administered for 30 min at the maximum tolerable intensity. The mean subcutaneous glucose concentration and mean amplitude of glycemic excursion (MAGE) were determined by flash glucose monitoring for 24 h. Changes in glycoalbumin and MAGE before and after NMES initiation were evaluated. The mean blood glucose level and MAGE after a single bout of NMES were significantly lower than those after rest. Glycoalbumin levels and echo intensity of the rectus femoris tended to decrease, but not significantly by ANOVA due to a lack in statistical power after the dropout of three patients. NMES in end-stage DKD decreased blood glucose levels during and after hemodialysis. MDPI 2022-10-22 /pmc/articles/PMC9658571/ /pubmed/36362467 http://dx.doi.org/10.3390/jcm11216239 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsurumi, Tomoki
Tamura, Yuma
Nakatani, Yuki
Furuya, Tomoki
Tamiya, Hajime
Terashima, Masato
Tomoe, Takashi
Ueno, Asuka
Shimoyama, Masahiro
Yasu, Takanori
Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
title Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
title_full Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
title_fullStr Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
title_full_unstemmed Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
title_short Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial
title_sort neuromuscular electrical stimulation during hemodialysis suppresses postprandial hyperglycemia in patients with end-stage diabetic kidney disease: a crossover controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658571/
https://www.ncbi.nlm.nih.gov/pubmed/36362467
http://dx.doi.org/10.3390/jcm11216239
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