Cargando…

miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention

In cervical cancer (CC), miR-23b-3p, miR-124-3p, and miR-218-5p have been found to act as tumor suppressors by regulating cellular processes related to progression and metastasis. The objective of the present review is to provide an update on the experimental evidence about the role of miR-23b-3p, m...

Descripción completa

Detalles Bibliográficos
Autores principales: Romero-López, Manuel Joaquín, Jiménez-Wences, Hilda, Cruz-De la Rosa, Merlin Itsel, Román-Fernández, Ilce Valeria, Fernández-Tilapa, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658720/
https://www.ncbi.nlm.nih.gov/pubmed/36362337
http://dx.doi.org/10.3390/ijms232113551
_version_ 1784830020993155072
author Romero-López, Manuel Joaquín
Jiménez-Wences, Hilda
Cruz-De la Rosa, Merlin Itsel
Román-Fernández, Ilce Valeria
Fernández-Tilapa, Gloria
author_facet Romero-López, Manuel Joaquín
Jiménez-Wences, Hilda
Cruz-De la Rosa, Merlin Itsel
Román-Fernández, Ilce Valeria
Fernández-Tilapa, Gloria
author_sort Romero-López, Manuel Joaquín
collection PubMed
description In cervical cancer (CC), miR-23b-3p, miR-124-3p, and miR-218-5p have been found to act as tumor suppressors by regulating cellular processes related to progression and metastasis. The objective of the present review is to provide an update on the experimental evidence about the role of miR-23b-3p, miR-124-3p, and miR-218-5p in the regulation of CC progression. Additionally, we present the results of a bioinformatic analysis that suggest that these miRNAs have a somewhat redundant role in the same cellular processes that may result in a synergistic effect to promote CC progression. The results indicate that specific and common target genes for miR-23b-3p, miR-124-3p, and miR-218-5p regulate proliferation, migration, apoptosis, and angiogenesis, all processes that are related to CC maintenance and progression. Furthermore, several target genes may regulate cancer-related signaling pathways. We found that a total of 271 proteins encoded by the target mRNAs of miR-23b-3p, miR-124-3p, or miR-218-5p interact to regulate the cellular processes previously mentioned, and some of these proteins are regulated by HPV-16 E7. Taken together, information analysis indicates that miR-23b-3p, miR-124-3p, and miR-218-5p may potentiate their effects to modulate the cellular processes related to the progression and maintenance of CC with and without HPV-16 involvement.
format Online
Article
Text
id pubmed-9658720
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96587202022-11-15 miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention Romero-López, Manuel Joaquín Jiménez-Wences, Hilda Cruz-De la Rosa, Merlin Itsel Román-Fernández, Ilce Valeria Fernández-Tilapa, Gloria Int J Mol Sci Review In cervical cancer (CC), miR-23b-3p, miR-124-3p, and miR-218-5p have been found to act as tumor suppressors by regulating cellular processes related to progression and metastasis. The objective of the present review is to provide an update on the experimental evidence about the role of miR-23b-3p, miR-124-3p, and miR-218-5p in the regulation of CC progression. Additionally, we present the results of a bioinformatic analysis that suggest that these miRNAs have a somewhat redundant role in the same cellular processes that may result in a synergistic effect to promote CC progression. The results indicate that specific and common target genes for miR-23b-3p, miR-124-3p, and miR-218-5p regulate proliferation, migration, apoptosis, and angiogenesis, all processes that are related to CC maintenance and progression. Furthermore, several target genes may regulate cancer-related signaling pathways. We found that a total of 271 proteins encoded by the target mRNAs of miR-23b-3p, miR-124-3p, or miR-218-5p interact to regulate the cellular processes previously mentioned, and some of these proteins are regulated by HPV-16 E7. Taken together, information analysis indicates that miR-23b-3p, miR-124-3p, and miR-218-5p may potentiate their effects to modulate the cellular processes related to the progression and maintenance of CC with and without HPV-16 involvement. MDPI 2022-11-04 /pmc/articles/PMC9658720/ /pubmed/36362337 http://dx.doi.org/10.3390/ijms232113551 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Romero-López, Manuel Joaquín
Jiménez-Wences, Hilda
Cruz-De la Rosa, Merlin Itsel
Román-Fernández, Ilce Valeria
Fernández-Tilapa, Gloria
miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention
title miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention
title_full miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention
title_fullStr miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention
title_full_unstemmed miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention
title_short miR-23b-3p, miR-124-3p and miR-218-5p Synergistic or Additive Effects on Cellular Processes That Modulate Cervical Cancer Progression? A Molecular Balance That Needs Attention
title_sort mir-23b-3p, mir-124-3p and mir-218-5p synergistic or additive effects on cellular processes that modulate cervical cancer progression? a molecular balance that needs attention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658720/
https://www.ncbi.nlm.nih.gov/pubmed/36362337
http://dx.doi.org/10.3390/ijms232113551
work_keys_str_mv AT romerolopezmanueljoaquin mir23b3pmir1243pandmir2185psynergisticoradditiveeffectsoncellularprocessesthatmodulatecervicalcancerprogressionamolecularbalancethatneedsattention
AT jimenezwenceshilda mir23b3pmir1243pandmir2185psynergisticoradditiveeffectsoncellularprocessesthatmodulatecervicalcancerprogressionamolecularbalancethatneedsattention
AT cruzdelarosamerlinitsel mir23b3pmir1243pandmir2185psynergisticoradditiveeffectsoncellularprocessesthatmodulatecervicalcancerprogressionamolecularbalancethatneedsattention
AT romanfernandezilcevaleria mir23b3pmir1243pandmir2185psynergisticoradditiveeffectsoncellularprocessesthatmodulatecervicalcancerprogressionamolecularbalancethatneedsattention
AT fernandeztilapagloria mir23b3pmir1243pandmir2185psynergisticoradditiveeffectsoncellularprocessesthatmodulatecervicalcancerprogressionamolecularbalancethatneedsattention