Cargando…

Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets

Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by the lymphocytic infiltration of exocrine glands and the production of autoantibodies to self-antigens. The involvement of the exocrine glands drives the pathognomonic manifestations of dry eyes (keratoconjunctivitis...

Descripción completa

Detalles Bibliográficos
Autores principales: Sisto, Margherita, Ribatti, Domenico, Lisi, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658723/
https://www.ncbi.nlm.nih.gov/pubmed/36362017
http://dx.doi.org/10.3390/ijms232113229
_version_ 1784830021821530112
author Sisto, Margherita
Ribatti, Domenico
Lisi, Sabrina
author_facet Sisto, Margherita
Ribatti, Domenico
Lisi, Sabrina
author_sort Sisto, Margherita
collection PubMed
description Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by the lymphocytic infiltration of exocrine glands and the production of autoantibodies to self-antigens. The involvement of the exocrine glands drives the pathognomonic manifestations of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) that define sicca syndrome. To date, the molecular mechanisms mediating pathological salivary gland dysfunction in SS remain to be elucidated, despite extensive studies investigating the underlying cause of this disease, hampering the development of novel therapeutic strategies. Many researchers have identified a multifactorial pathogenesis of SS, including environmental, genetic, neuroendocrine, and immune factors. In this review, we explore the latest developments in understanding the molecular mechanisms involved in the pathogenesis of SS, which have attracted increasing interest in recent years.
format Online
Article
Text
id pubmed-9658723
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96587232022-11-15 Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets Sisto, Margherita Ribatti, Domenico Lisi, Sabrina Int J Mol Sci Review Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by the lymphocytic infiltration of exocrine glands and the production of autoantibodies to self-antigens. The involvement of the exocrine glands drives the pathognomonic manifestations of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) that define sicca syndrome. To date, the molecular mechanisms mediating pathological salivary gland dysfunction in SS remain to be elucidated, despite extensive studies investigating the underlying cause of this disease, hampering the development of novel therapeutic strategies. Many researchers have identified a multifactorial pathogenesis of SS, including environmental, genetic, neuroendocrine, and immune factors. In this review, we explore the latest developments in understanding the molecular mechanisms involved in the pathogenesis of SS, which have attracted increasing interest in recent years. MDPI 2022-10-30 /pmc/articles/PMC9658723/ /pubmed/36362017 http://dx.doi.org/10.3390/ijms232113229 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sisto, Margherita
Ribatti, Domenico
Lisi, Sabrina
Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets
title Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets
title_full Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets
title_fullStr Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets
title_full_unstemmed Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets
title_short Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets
title_sort molecular mechanisms linking inflammation to autoimmunity in sjögren’s syndrome: identification of new targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658723/
https://www.ncbi.nlm.nih.gov/pubmed/36362017
http://dx.doi.org/10.3390/ijms232113229
work_keys_str_mv AT sistomargherita molecularmechanismslinkinginflammationtoautoimmunityinsjogrenssyndromeidentificationofnewtargets
AT ribattidomenico molecularmechanismslinkinginflammationtoautoimmunityinsjogrenssyndromeidentificationofnewtargets
AT lisisabrina molecularmechanismslinkinginflammationtoautoimmunityinsjogrenssyndromeidentificationofnewtargets