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Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome
Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658734/ https://www.ncbi.nlm.nih.gov/pubmed/36364922 http://dx.doi.org/10.3390/nu14214660 |
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author | Bettag, Jeffery Po, Loren Cunningham, Cassius Tallam, Rahul Kurashima, Kento Nagarapu, Aakash Hutchinson, Chelsea Morfin, Sylvia Nazzal, Mustafa Lin, Chien-Jung Mathur, Amit Aurora, Rajeev Jain, Ajay K. |
author_facet | Bettag, Jeffery Po, Loren Cunningham, Cassius Tallam, Rahul Kurashima, Kento Nagarapu, Aakash Hutchinson, Chelsea Morfin, Sylvia Nazzal, Mustafa Lin, Chien-Jung Mathur, Amit Aurora, Rajeev Jain, Ajay K. |
author_sort | Bettag, Jeffery |
collection | PubMed |
description | Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut–brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury. |
format | Online Article Text |
id | pubmed-9658734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96587342022-11-15 Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome Bettag, Jeffery Po, Loren Cunningham, Cassius Tallam, Rahul Kurashima, Kento Nagarapu, Aakash Hutchinson, Chelsea Morfin, Sylvia Nazzal, Mustafa Lin, Chien-Jung Mathur, Amit Aurora, Rajeev Jain, Ajay K. Nutrients Review Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut–brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury. MDPI 2022-11-04 /pmc/articles/PMC9658734/ /pubmed/36364922 http://dx.doi.org/10.3390/nu14214660 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bettag, Jeffery Po, Loren Cunningham, Cassius Tallam, Rahul Kurashima, Kento Nagarapu, Aakash Hutchinson, Chelsea Morfin, Sylvia Nazzal, Mustafa Lin, Chien-Jung Mathur, Amit Aurora, Rajeev Jain, Ajay K. Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
title | Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
title_full | Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
title_fullStr | Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
title_full_unstemmed | Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
title_short | Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
title_sort | novel therapeutic approaches for mitigating complications in short bowel syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658734/ https://www.ncbi.nlm.nih.gov/pubmed/36364922 http://dx.doi.org/10.3390/nu14214660 |
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