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Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways

Background: Europinidin is a derivative of delphinidin obtained from the plants Plumbago Europea and Ceratostigma plumbaginoides. This herb has wide medicinal applications in treating various diseases but there are very few studies available on this bioactive compound. Considering this background, t...

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Autores principales: Altharawi, Ali, Alharthy, Khalid M., Althurwi, Hassan N., Albaqami, Faisal F., Alzarea, Sami I., Al-Abbasi, Fahad A., Nadeem, Muhammad Shahid, Kazmi, Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658735/
https://www.ncbi.nlm.nih.gov/pubmed/36363986
http://dx.doi.org/10.3390/molecules27217159
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author Altharawi, Ali
Alharthy, Khalid M.
Althurwi, Hassan N.
Albaqami, Faisal F.
Alzarea, Sami I.
Al-Abbasi, Fahad A.
Nadeem, Muhammad Shahid
Kazmi, Imran
author_facet Altharawi, Ali
Alharthy, Khalid M.
Althurwi, Hassan N.
Albaqami, Faisal F.
Alzarea, Sami I.
Al-Abbasi, Fahad A.
Nadeem, Muhammad Shahid
Kazmi, Imran
author_sort Altharawi, Ali
collection PubMed
description Background: Europinidin is a derivative of delphinidin obtained from the plants Plumbago Europea and Ceratostigma plumbaginoides. This herb has wide medicinal applications in treating various diseases but there are very few studies available on this bioactive compound. Considering this background, the present study is designed for the evaluation of Europinidin against Parkinson’s disease. Aim: The investigation aims to assess the effect of Europinidin in the rotenone-activated Parkinson’s paradigm. Methods: To evaluate neuroprotective activity, rotenone (1.5 mg/kg s.c) and europinidin (10 mg/kg and 20 mg/kg) was administered in rats for 21 days. The behavioural parameters were performed before sacrificing the rats. On the 22nd day, all the rats were assessed for biochemical markers (SOD, GSH, MDA, Catalase), neurotransmitter levels (Dopamine, 5-HIAA, DOPAC, and HVA levels), and neuroinflammatory markers (IL-6, IL-1β and TNF-α). Results: It was found that rotenone produced significant (p < 0.001) oxidative damage, a cholinergic deficit, dopaminergic loss, and a rise in neuroinflammatory markers in rats. Conclusion: The study concludes that europinidin possesses anti-oxidant and anti-inflammatory properties. The results suggest the therapeutic role of europinidin against rotenone-activated behavioural, biochemical, and neuroinflammatory alterations in rats.
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spelling pubmed-96587352022-11-15 Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways Altharawi, Ali Alharthy, Khalid M. Althurwi, Hassan N. Albaqami, Faisal F. Alzarea, Sami I. Al-Abbasi, Fahad A. Nadeem, Muhammad Shahid Kazmi, Imran Molecules Article Background: Europinidin is a derivative of delphinidin obtained from the plants Plumbago Europea and Ceratostigma plumbaginoides. This herb has wide medicinal applications in treating various diseases but there are very few studies available on this bioactive compound. Considering this background, the present study is designed for the evaluation of Europinidin against Parkinson’s disease. Aim: The investigation aims to assess the effect of Europinidin in the rotenone-activated Parkinson’s paradigm. Methods: To evaluate neuroprotective activity, rotenone (1.5 mg/kg s.c) and europinidin (10 mg/kg and 20 mg/kg) was administered in rats for 21 days. The behavioural parameters were performed before sacrificing the rats. On the 22nd day, all the rats were assessed for biochemical markers (SOD, GSH, MDA, Catalase), neurotransmitter levels (Dopamine, 5-HIAA, DOPAC, and HVA levels), and neuroinflammatory markers (IL-6, IL-1β and TNF-α). Results: It was found that rotenone produced significant (p < 0.001) oxidative damage, a cholinergic deficit, dopaminergic loss, and a rise in neuroinflammatory markers in rats. Conclusion: The study concludes that europinidin possesses anti-oxidant and anti-inflammatory properties. The results suggest the therapeutic role of europinidin against rotenone-activated behavioural, biochemical, and neuroinflammatory alterations in rats. MDPI 2022-10-23 /pmc/articles/PMC9658735/ /pubmed/36363986 http://dx.doi.org/10.3390/molecules27217159 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Altharawi, Ali
Alharthy, Khalid M.
Althurwi, Hassan N.
Albaqami, Faisal F.
Alzarea, Sami I.
Al-Abbasi, Fahad A.
Nadeem, Muhammad Shahid
Kazmi, Imran
Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways
title Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways
title_full Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways
title_fullStr Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways
title_full_unstemmed Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways
title_short Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways
title_sort europinidin inhibits rotenone-activated parkinson’s disease in rodents by decreasing lipid peroxidation and inflammatory cytokines pathways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658735/
https://www.ncbi.nlm.nih.gov/pubmed/36363986
http://dx.doi.org/10.3390/molecules27217159
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