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Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature
Multicentric reticulohistiocytosis (MRH) is the most frequently described form of reticulohistiocytosis (RH), and it is classified as a class IIb non-Langerhans cell histiocytosis. It has been designated as multicentric, being characterized by multisystemic involvement. In fact, although mainly invo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658768/ https://www.ncbi.nlm.nih.gov/pubmed/36362761 http://dx.doi.org/10.3390/jcm11216529 |
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author | Mariotti, Elena Biancamaria Corrà, Alberto Lemmi, Elisa Laschi, Lucrezia Aimo, Cristina Quintarelli, Lavinia Volpi, Walter Nacci, Francesca Verdelli, Alice Ruffo di Calabria, Valentina Guiducci, Serena Caproni, Marzia |
author_facet | Mariotti, Elena Biancamaria Corrà, Alberto Lemmi, Elisa Laschi, Lucrezia Aimo, Cristina Quintarelli, Lavinia Volpi, Walter Nacci, Francesca Verdelli, Alice Ruffo di Calabria, Valentina Guiducci, Serena Caproni, Marzia |
author_sort | Mariotti, Elena Biancamaria |
collection | PubMed |
description | Multicentric reticulohistiocytosis (MRH) is the most frequently described form of reticulohistiocytosis (RH), and it is classified as a class IIb non-Langerhans cell histiocytosis. It has been designated as multicentric, being characterized by multisystemic involvement. In fact, although mainly involving the skin, along with the joints, it is a systemic inflammatory condition potentially involving every internal organ. As MRH-related skin findings can mimic rheumatoid nodules or Gottron papules, the histopathology of the cutaneous lesions is often necessary for the correct diagnosis. Approximately one-third of MRH patients have confirmed concomitant autoimmune disorders. A wide variety of autoimmune disorders associated with the disease have been reported in the literature, suggesting immune dysfunction as a factor in the pathophysiology of MRH. A case of MRH associated with autoimmune manifestation is reported in the context of a mini review of the literature, with a focus on clinical presentation, treatments, and treatment outcomes. Moreover, eight cases of MRH associated with autoimmune diseases are briefly discussed. |
format | Online Article Text |
id | pubmed-9658768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96587682022-11-15 Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature Mariotti, Elena Biancamaria Corrà, Alberto Lemmi, Elisa Laschi, Lucrezia Aimo, Cristina Quintarelli, Lavinia Volpi, Walter Nacci, Francesca Verdelli, Alice Ruffo di Calabria, Valentina Guiducci, Serena Caproni, Marzia J Clin Med Review Multicentric reticulohistiocytosis (MRH) is the most frequently described form of reticulohistiocytosis (RH), and it is classified as a class IIb non-Langerhans cell histiocytosis. It has been designated as multicentric, being characterized by multisystemic involvement. In fact, although mainly involving the skin, along with the joints, it is a systemic inflammatory condition potentially involving every internal organ. As MRH-related skin findings can mimic rheumatoid nodules or Gottron papules, the histopathology of the cutaneous lesions is often necessary for the correct diagnosis. Approximately one-third of MRH patients have confirmed concomitant autoimmune disorders. A wide variety of autoimmune disorders associated with the disease have been reported in the literature, suggesting immune dysfunction as a factor in the pathophysiology of MRH. A case of MRH associated with autoimmune manifestation is reported in the context of a mini review of the literature, with a focus on clinical presentation, treatments, and treatment outcomes. Moreover, eight cases of MRH associated with autoimmune diseases are briefly discussed. MDPI 2022-11-03 /pmc/articles/PMC9658768/ /pubmed/36362761 http://dx.doi.org/10.3390/jcm11216529 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mariotti, Elena Biancamaria Corrà, Alberto Lemmi, Elisa Laschi, Lucrezia Aimo, Cristina Quintarelli, Lavinia Volpi, Walter Nacci, Francesca Verdelli, Alice Ruffo di Calabria, Valentina Guiducci, Serena Caproni, Marzia Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature |
title | Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature |
title_full | Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature |
title_fullStr | Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature |
title_full_unstemmed | Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature |
title_short | Multicentric Reticulohistiocytosis Associated with an Early Form of Systemic Lupus Erythematosus: A Case Report of a Rare Disease, with Mini Review of the Literature |
title_sort | multicentric reticulohistiocytosis associated with an early form of systemic lupus erythematosus: a case report of a rare disease, with mini review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658768/ https://www.ncbi.nlm.nih.gov/pubmed/36362761 http://dx.doi.org/10.3390/jcm11216529 |
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