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Sabizabulin, a Potent Orally Bioavailable Colchicine Binding Site Agent, Suppresses HER2+ Breast Cancer and Metastasis

SIMPLE SUMMARY: The sabizabulin agent represses tumor cell growth, cell migration, and colony formation, and induces cell death in HER2+ breast cancer models. Sabizabulin is comparable to paclitaxel to suppress HER2+ xenograft growth and to inhibit lung metastasis in a HER2+ patient-derived xenograf...

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Detalles Bibliográficos
Autores principales:	Krutilina, Raisa I., Hartman, Kelli L., Oluwalana, Damilola, Playa, Hilaire C., Parke, Deanna N., Chen, Hao, Miller, Duane D., Li, Wei, Seagroves, Tiffany N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658816/ https://www.ncbi.nlm.nih.gov/pubmed/36358755 http://dx.doi.org/10.3390/cancers14215336

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