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Phosphate Dysregulation and Metabolic Syndrome

Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflamma...

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Autores principales: Mironov, Nikolay, Haque, Mainul, Atfi, Azeddine, Razzaque, Mohammed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658852/
https://www.ncbi.nlm.nih.gov/pubmed/36364739
http://dx.doi.org/10.3390/nu14214477
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author Mironov, Nikolay
Haque, Mainul
Atfi, Azeddine
Razzaque, Mohammed S.
author_facet Mironov, Nikolay
Haque, Mainul
Atfi, Azeddine
Razzaque, Mohammed S.
author_sort Mironov, Nikolay
collection PubMed
description Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual’s risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.
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spelling pubmed-96588522022-11-15 Phosphate Dysregulation and Metabolic Syndrome Mironov, Nikolay Haque, Mainul Atfi, Azeddine Razzaque, Mohammed S. Nutrients Commentary Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual’s risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population. MDPI 2022-10-25 /pmc/articles/PMC9658852/ /pubmed/36364739 http://dx.doi.org/10.3390/nu14214477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Mironov, Nikolay
Haque, Mainul
Atfi, Azeddine
Razzaque, Mohammed S.
Phosphate Dysregulation and Metabolic Syndrome
title Phosphate Dysregulation and Metabolic Syndrome
title_full Phosphate Dysregulation and Metabolic Syndrome
title_fullStr Phosphate Dysregulation and Metabolic Syndrome
title_full_unstemmed Phosphate Dysregulation and Metabolic Syndrome
title_short Phosphate Dysregulation and Metabolic Syndrome
title_sort phosphate dysregulation and metabolic syndrome
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658852/
https://www.ncbi.nlm.nih.gov/pubmed/36364739
http://dx.doi.org/10.3390/nu14214477
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