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Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients

SIMPLE SUMMARY: Microsporidia infection has been related to the malignant process of epithelial cells. We found a high prevalence of microsporidia in the intestinal tissues of patients with Colon Cancer (CC) vs tissues of healthy subjects. This observation could suggest a relationship between micros...

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Autores principales: Redondo, Fernando, Hurtado-Marcos, Carolina, Izquierdo, Fernando, Cuéllar, Carmen, Fenoy, Soledad, Sáez, Yanira, Magnet, Ángela, Galindo-Regal, Lorena, Uribe, Natalia, López-Bañeres, Manuel, Jiménez, Ana Isabel, Llombart-Cussac, Antonio, Del Águila, Carmen, Andreu-Ballester, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658866/
https://www.ncbi.nlm.nih.gov/pubmed/36358760
http://dx.doi.org/10.3390/cancers14215342
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author Redondo, Fernando
Hurtado-Marcos, Carolina
Izquierdo, Fernando
Cuéllar, Carmen
Fenoy, Soledad
Sáez, Yanira
Magnet, Ángela
Galindo-Regal, Lorena
Uribe, Natalia
López-Bañeres, Manuel
Jiménez, Ana Isabel
Llombart-Cussac, Antonio
Del Águila, Carmen
Andreu-Ballester, Juan Carlos
author_facet Redondo, Fernando
Hurtado-Marcos, Carolina
Izquierdo, Fernando
Cuéllar, Carmen
Fenoy, Soledad
Sáez, Yanira
Magnet, Ángela
Galindo-Regal, Lorena
Uribe, Natalia
López-Bañeres, Manuel
Jiménez, Ana Isabel
Llombart-Cussac, Antonio
Del Águila, Carmen
Andreu-Ballester, Juan Carlos
author_sort Redondo, Fernando
collection PubMed
description SIMPLE SUMMARY: Microsporidia infection has been related to the malignant process of epithelial cells. We found a high prevalence of microsporidia in the intestinal tissues of patients with Colon Cancer (CC) vs tissues of healthy subjects. This observation could suggest a relationship between microsporidia and the etiopathogenesis of CC. ABSTRACT: Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p < 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.
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spelling pubmed-96588662022-11-15 Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients Redondo, Fernando Hurtado-Marcos, Carolina Izquierdo, Fernando Cuéllar, Carmen Fenoy, Soledad Sáez, Yanira Magnet, Ángela Galindo-Regal, Lorena Uribe, Natalia López-Bañeres, Manuel Jiménez, Ana Isabel Llombart-Cussac, Antonio Del Águila, Carmen Andreu-Ballester, Juan Carlos Cancers (Basel) Article SIMPLE SUMMARY: Microsporidia infection has been related to the malignant process of epithelial cells. We found a high prevalence of microsporidia in the intestinal tissues of patients with Colon Cancer (CC) vs tissues of healthy subjects. This observation could suggest a relationship between microsporidia and the etiopathogenesis of CC. ABSTRACT: Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p < 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC. MDPI 2022-10-29 /pmc/articles/PMC9658866/ /pubmed/36358760 http://dx.doi.org/10.3390/cancers14215342 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Redondo, Fernando
Hurtado-Marcos, Carolina
Izquierdo, Fernando
Cuéllar, Carmen
Fenoy, Soledad
Sáez, Yanira
Magnet, Ángela
Galindo-Regal, Lorena
Uribe, Natalia
López-Bañeres, Manuel
Jiménez, Ana Isabel
Llombart-Cussac, Antonio
Del Águila, Carmen
Andreu-Ballester, Juan Carlos
Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
title Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
title_full Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
title_fullStr Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
title_full_unstemmed Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
title_short Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
title_sort latent microsporidia infection prevalence as a risk factor in colon cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658866/
https://www.ncbi.nlm.nih.gov/pubmed/36358760
http://dx.doi.org/10.3390/cancers14215342
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