Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye

Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (AD...

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Detalles Bibliográficos
Autores principales: Maugeri, Grazia, D’Amico, Agata Grazia, Magrì, Benedetta, Musumeci, Giuseppe, D’Agata, Velia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658893/
https://www.ncbi.nlm.nih.gov/pubmed/36362439
http://dx.doi.org/10.3390/ijms232113654
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author Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
Musumeci, Giuseppe
D’Agata, Velia
author_facet Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
Musumeci, Giuseppe
D’Agata, Velia
author_sort Maugeri, Grazia
collection PubMed
description Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (ADNP) is a protein involved in the physio-pathological processes of the eye. Noteworthy, is the small peptide derived from ADNP, known as NAP, which shows protective, antioxidant, and anti-apoptotic properties. Herein, we review the current state of knowledge concerning the role of ADNP in ocular pathologies, while providing an overview of eye anatomy.
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spelling pubmed-96588932022-11-15 Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye Maugeri, Grazia D’Amico, Agata Grazia Magrì, Benedetta Musumeci, Giuseppe D’Agata, Velia Int J Mol Sci Review Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (ADNP) is a protein involved in the physio-pathological processes of the eye. Noteworthy, is the small peptide derived from ADNP, known as NAP, which shows protective, antioxidant, and anti-apoptotic properties. Herein, we review the current state of knowledge concerning the role of ADNP in ocular pathologies, while providing an overview of eye anatomy. MDPI 2022-11-07 /pmc/articles/PMC9658893/ /pubmed/36362439 http://dx.doi.org/10.3390/ijms232113654 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
Musumeci, Giuseppe
D’Agata, Velia
Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
title Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
title_full Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
title_fullStr Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
title_full_unstemmed Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
title_short Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
title_sort activity-dependent neuroprotective protein (adnp): an overview of its role in the eye
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658893/
https://www.ncbi.nlm.nih.gov/pubmed/36362439
http://dx.doi.org/10.3390/ijms232113654
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