Structural Analysis of the Complex of Human Transthyretin with 3′,5′-Dichlorophenylanthranilic Acid at 1.5 Å Resolution

Human transthyretin (hTTR) can form amyloid deposits that accumulate in nerves and organs, disrupting cellular function. Molecules such as tafamidis that bind to and stabilize the TTR tetramer can reduce such amyloid formation. Here, we studied the interaction of VCP-6 (2-((3,5-dichlorophenyl)amino)...

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Detalles Bibliográficos
Autores principales: Cody, Vivian, Truong, Jia Q., Holdsworth, Bruce A., Holien, Jessica K., Richardson, Samantha J., Chalmers, David K., Craik, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659241/
https://www.ncbi.nlm.nih.gov/pubmed/36364032
http://dx.doi.org/10.3390/molecules27217206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659241/
https://www.ncbi.nlm.nih.gov/pubmed/36364032
http://dx.doi.org/10.3390/molecules27217206

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