2-Imidazoline Nitroxide Derivatives of Cymantrene

The 2-imidazoline nitroxide derivatives of cymantrene—2-(η(5)-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (NNMn) and 2-(η(5)-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl (INMn) were synthesized....

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Autores principales: Maryunina, Kseniya, Letyagin, Gleb, Romanenko, Galina, Bogomyakov, Artem, Morozov, Vitaly, Tumanov, Sergey, Veber, Sergey, Fedin, Matvey, Saverina, Evgeniya, Syroeshkin, Mikhail, Egorov, Mikhail, Ovcharenko, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659262/
https://www.ncbi.nlm.nih.gov/pubmed/36364372
http://dx.doi.org/10.3390/molecules27217545
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author Maryunina, Kseniya
Letyagin, Gleb
Romanenko, Galina
Bogomyakov, Artem
Morozov, Vitaly
Tumanov, Sergey
Veber, Sergey
Fedin, Matvey
Saverina, Evgeniya
Syroeshkin, Mikhail
Egorov, Mikhail
Ovcharenko, Victor
author_facet Maryunina, Kseniya
Letyagin, Gleb
Romanenko, Galina
Bogomyakov, Artem
Morozov, Vitaly
Tumanov, Sergey
Veber, Sergey
Fedin, Matvey
Saverina, Evgeniya
Syroeshkin, Mikhail
Egorov, Mikhail
Ovcharenko, Victor
author_sort Maryunina, Kseniya
collection PubMed
description The 2-imidazoline nitroxide derivatives of cymantrene—2-(η(5)-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (NNMn) and 2-(η(5)-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl (INMn) were synthesized. It was shown that NNMn and INMn exhibit a sufficiently high kinetic stability both in solids and in solutions under normal conditions. Their structural characteristics, magnetic properties and electrochemical behavior are close to Re(I) analogs. This opens the prospect of using paramagnetic cymantrenes as prototypes in the design of Re(I) half-sandwiched derivatives for theranostics, where therapy is combined with diagnostics by magnetic resonance imaging due to the contrast properties of nitroxide radicals.
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spelling pubmed-96592622022-11-15 2-Imidazoline Nitroxide Derivatives of Cymantrene Maryunina, Kseniya Letyagin, Gleb Romanenko, Galina Bogomyakov, Artem Morozov, Vitaly Tumanov, Sergey Veber, Sergey Fedin, Matvey Saverina, Evgeniya Syroeshkin, Mikhail Egorov, Mikhail Ovcharenko, Victor Molecules Article The 2-imidazoline nitroxide derivatives of cymantrene—2-(η(5)-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (NNMn) and 2-(η(5)-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl (INMn) were synthesized. It was shown that NNMn and INMn exhibit a sufficiently high kinetic stability both in solids and in solutions under normal conditions. Their structural characteristics, magnetic properties and electrochemical behavior are close to Re(I) analogs. This opens the prospect of using paramagnetic cymantrenes as prototypes in the design of Re(I) half-sandwiched derivatives for theranostics, where therapy is combined with diagnostics by magnetic resonance imaging due to the contrast properties of nitroxide radicals. MDPI 2022-11-03 /pmc/articles/PMC9659262/ /pubmed/36364372 http://dx.doi.org/10.3390/molecules27217545 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maryunina, Kseniya
Letyagin, Gleb
Romanenko, Galina
Bogomyakov, Artem
Morozov, Vitaly
Tumanov, Sergey
Veber, Sergey
Fedin, Matvey
Saverina, Evgeniya
Syroeshkin, Mikhail
Egorov, Mikhail
Ovcharenko, Victor
2-Imidazoline Nitroxide Derivatives of Cymantrene
title 2-Imidazoline Nitroxide Derivatives of Cymantrene
title_full 2-Imidazoline Nitroxide Derivatives of Cymantrene
title_fullStr 2-Imidazoline Nitroxide Derivatives of Cymantrene
title_full_unstemmed 2-Imidazoline Nitroxide Derivatives of Cymantrene
title_short 2-Imidazoline Nitroxide Derivatives of Cymantrene
title_sort 2-imidazoline nitroxide derivatives of cymantrene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659262/
https://www.ncbi.nlm.nih.gov/pubmed/36364372
http://dx.doi.org/10.3390/molecules27217545
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