Cargando…

Natural and Synthetic Xanthone Derivatives Counteract Oxidative Stress via Nrf2 Modulation in Inflamed Human Macrophages

Natural products have attracted attention due to their safety and potential effectiveness as anti-inflammatory drugs. Particularly, xanthones owning a unique 9H-xanthen-9-one scaffold, are endowed with a large diversity of medical applications, including antioxidant and anti-inflammatory activities,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallorini, Marialucia, Carradori, Simone, Resende, Diana I. S. P., Saso, Luciano, Ricci, Alessia, Palmeira, Andreia, Cataldi, Amelia, Pinto, Madalena, Sousa, Emília
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659273/ https://www.ncbi.nlm.nih.gov/pubmed/36362104 http://dx.doi.org/10.3390/ijms232113319

Ejemplares similares

From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones
por: Pinto, Madalena M. M., et al.
Publicado: (2021)

Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria
por: Durães, Fernando, et al.
Publicado: (2021)

Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone
por: Pedro Gonçalves, A., et al.
Publicado: (2015)

From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents
por: Resende, Diana I. S. P., et al.
Publicado: (2021)

Phenylsulfonimide PPARα Antagonists Enhance Nrf2 Activation and Promote Oxidative Stress-Induced Apoptosis/Pyroptosis in MCF7 Breast Cancer Cells
por: Gallorini, Marialucia, et al.
Publicado: (2023)

Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model
por: Ricci, Alessia, et al.
Publicado: (2022)

Kinesin Eg5 Selective Inhibition by Newly Synthesized Molecules as an Alternative Approach to Counteract Breast Cancer Progression: An In Vitro Study
por: Ricci, Alessia, et al.
Publicado: (2022)

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation
por: Ricci, Alessia, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents
por: Lemos, Agostinho, et al.
Publicado: (2019)

Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection
por: Elsallabi, Osama, et al.
Publicado: (2022)

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis
por: Barbosa, João, et al.
Publicado: (2016)

Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones
por: Almeida, Joana R., et al.
Publicado: (2020)

Lichen Xanthones as Models for New Antifungal Agents
por: Resende, Diana I. S. P., et al.
Publicado: (2018)

The Up-Regulation of Oxidative Stress as a Potential Mechanism of Novel MAO-B Inhibitors for Glioblastoma Treatment
por: Marconi, Guya Diletta, et al.
Publicado: (2019)

Dual Acting Carbon Monoxide Releasing Molecules and Carbonic Anhydrase Inhibitors Differentially Modulate Inflammation in Human Tenocytes
por: Gallorini, Marialucia, et al.
Publicado: (2021)

Snail Slime Extracted by a Cruelty Free Method Preserves Viability and Controls Inflammation Occurrence: A Focus on Fibroblasts
por: Ricci, Alessia, et al.
Publicado: (2023)

Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns
por: Phyo, Ye‛ Zaw, et al.
Publicado: (2018)

Relevance of Cellular Redox Homeostasis for Vital Functions of Human Dental Pulp Cells
por: Gallorini, Marialucia, et al.
Publicado: (2021)

The Open Cell Form of 3D-Printed Titanium Improves Osteconductive Properties and Adhesion Behavior of Dental Pulp Stem Cells
por: Gallorini, Marialucia, et al.
Publicado: (2021)

Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies
por: Fernandes, Carla, et al.
Publicado: (2019)

A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes
por: Appetecchia, Federico, et al.
Publicado: (2021)

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: In Vitro, Ex Vivo, and In Silico Studies
por: Martins, Eva, et al.
Publicado: (2019)

Conjugation with Methylsulfonylmethane Improves Hyaluronic Acid Anti-Inflammatory Activity in a Hydrogen Peroxide-Exposed Tenocyte Culture In Vitro Model
por: Oliva, Francesco, et al.
Publicado: (2020)

Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity
por: Resende, Diana I. S. P., et al.
Publicado: (2020)

3,4-Dioxygenated xanthones as antifouling additives for marine coatings: in silico studies, seawater solubility, degradability, leaching, and antifouling performance
por: Vilas-Boas, Cátia, et al.
Publicado: (2023)

Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker
por: Alagöz, Mehmet Abdullah, et al.
Publicado: (2021)

Chiral Derivatives of Xanthones with Antimicrobial Activity
por: Araújo, Joana, et al.
Publicado: (2019)

Redox Control of IL-6-Mediated Dental Pulp Stem-Cell Differentiation on Alginate/Hydroxyapatite Biocomposites for Bone Ingrowth
por: Sancilio, Silvia, et al.
Publicado: (2019)

Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria
por: Durães, Fernando, et al.
Publicado: (2021)

New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study
por: Maccallini, Cristina, et al.
Publicado: (2021)

Antitumor Activity of Some Prenylated Xanthones
por: Castanheiro, Raquel A. P., et al.
Publicado: (2009)

Selective Inhibitors of the Inducible Nitric Oxide Synthase as Modulators of Cell Responses in LPS-Stimulated Human Monocytes
por: Gallorini, Marialucia, et al.
Publicado: (2021)

Bioactive Marine Xanthones: A Review
por: Soares, José X., et al.
Publicado: (2022)

Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging
por: Resende, Diana I. S. P., et al.
Publicado: (2020)

Hyaluronic Acid Alleviates Oxidative Stress and Apoptosis in Human Tenocytes via Caspase 3 and 7
por: Gallorini, Marialucia, et al.
Publicado: (2022)

The Inhibition of the Inducible Nitric Oxide Synthase Enhances the DPSC Mineralization under LPS-Induced Inflammation
por: Cataldi, Amelia, et al.
Publicado: (2022)

Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations
por: Alves, Ana, et al.
Publicado: (2019)

Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin
por: Fernandes, Carla, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2021)

Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment
por: Marconi, Guya Diletta, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m2cq0mrfkdlffgmrnhoo00ie2u