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The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11

Inflammatory pathways usually utilize negative feedback regulatory systems to prevent tissue damage arising from excessive inflammatory response. Whether such negative feedback mechanisms exist in inflammasome activation remains unknown. Gasdermin D (GSDMD) is the pyroptosis executioner of downstrea...

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Detalles Bibliográficos
Autores principales:	Hu, Yingchao, Jiang, Yuying, Li, Sheng, Ma, Xiaoqing, Chen, Min, Yang, Rui, Wen, Shuang, Moynagh, Paul N., Wang, Bingwei, Hu, Gang, Yang, Shuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659347/ https://www.ncbi.nlm.nih.gov/pubmed/36322773 http://dx.doi.org/10.1073/pnas.2210809119

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