Omics analyses of a somatic Trp53(R245W/+) breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling

Alterations of the tumor suppressor TP53, one of the most common events in cancer, alone are insufficient for tumor development but serve as drivers of transformation. We sought to identify cooperating events through genomic analyses of a somatic Trp53(R245W) mouse model (equivalent to the TP53(R248...

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Detalles Bibliográficos
Autores principales: Yu, Xiaojie, Zhang, Yun, Xiong, Shunbin, McDaniel, Joy M., Sun, Chang, Chau, Gilda P., Gencel-Augusto, Jovanka, Chachad, Dhruv, Morrissey, Rhiannon L., Rao, Xiayu, Wang, Jing, Lozano, Guillermina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659373/
https://www.ncbi.nlm.nih.gov/pubmed/36322759
http://dx.doi.org/10.1073/pnas.2210618119

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