A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth

Citrate is a critical metabolic substrate and key regulator of energy metabolism in mammalian cells. It has been known for decades that the skeleton contains most (>85%) of the body’s citrate, but the question of why and how this metabolite should be partitioned in bone has received singularly li...

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Detalles Bibliográficos
Autores principales: Dirckx, Naomi, Zhang, Qian, Chu, Emily Y., Tower, Robert J., Li, Zhu, Guo, Shenghao, Yuan, Shichen, Khare, Pratik A., Zhang, Cissy, Verardo, Angela, Alejandro, Lucy O., Park, Angelina, Faugere, Marie-Claude, Helfand, Stephen L., Somerman, Martha J., Riddle, Ryan C., de Cabo, Rafael, Le, Anne, Schmidt-Rohr, Klaus, Clemens, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659386/
https://www.ncbi.nlm.nih.gov/pubmed/36322718
http://dx.doi.org/10.1073/pnas.2212178119

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