Cargando…

The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder

Alexithymia is characterized by impairments in the processing of emotions. Although the disruptions in the white matter (WM) integrity in Major depressive disorder (MDD) has frequently been reported, the underlying relationship with alexithymia remains unclear. In the present study, we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Youbin, Kim, Aram, Kang, Wooyoung, Han, Kyu-Man, Ham, Byoungjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659491/
https://www.ncbi.nlm.nih.gov/pubmed/36351844
http://dx.doi.org/10.5607/en22030
_version_ 1784830208851836928
author Kang, Youbin
Kim, Aram
Kang, Wooyoung
Han, Kyu-Man
Ham, Byoungjoo
author_facet Kang, Youbin
Kim, Aram
Kang, Wooyoung
Han, Kyu-Man
Ham, Byoungjoo
author_sort Kang, Youbin
collection PubMed
description Alexithymia is characterized by impairments in the processing of emotions. Although the disruptions in the white matter (WM) integrity in Major depressive disorder (MDD) has frequently been reported, the underlying relationship with alexithymia remains unclear. In the present study, we investigated WM tracts with Tracts Constrained by UnderLying Anatomy approach to discover potential associations between alexithymia and WM integrity to identify the neural basis of impaired emotional self-awareness in MDD. 101 patients with MDD and 99 healthy sex- and age-matched individuals underwent diffusion-weighted imaging. All participants were assessed with the 20-item Toronto Alexithymia Scale (TAS). TAS scores were significantly higher in MDD patients than in controls. Patients with MDD exhibited significantly lower FA values in the left inferior longitudinal fasciculus and it also showed negative associations with TAS. These results contribute to the neurobiological evidence on the association between MDD and alexithymia. Additionally, they suggest that reduced white matter integrity in the regions constitutes a principal pathophysiology underlying impaired emotional recognition and description in MDD.
format Online
Article
Text
id pubmed-9659491
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Korean Society for Brain and Neural Sciences
record_format MEDLINE/PubMed
spelling pubmed-96594912022-11-22 The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder Kang, Youbin Kim, Aram Kang, Wooyoung Han, Kyu-Man Ham, Byoungjoo Exp Neurobiol Short Communication Alexithymia is characterized by impairments in the processing of emotions. Although the disruptions in the white matter (WM) integrity in Major depressive disorder (MDD) has frequently been reported, the underlying relationship with alexithymia remains unclear. In the present study, we investigated WM tracts with Tracts Constrained by UnderLying Anatomy approach to discover potential associations between alexithymia and WM integrity to identify the neural basis of impaired emotional self-awareness in MDD. 101 patients with MDD and 99 healthy sex- and age-matched individuals underwent diffusion-weighted imaging. All participants were assessed with the 20-item Toronto Alexithymia Scale (TAS). TAS scores were significantly higher in MDD patients than in controls. Patients with MDD exhibited significantly lower FA values in the left inferior longitudinal fasciculus and it also showed negative associations with TAS. These results contribute to the neurobiological evidence on the association between MDD and alexithymia. Additionally, they suggest that reduced white matter integrity in the regions constitutes a principal pathophysiology underlying impaired emotional recognition and description in MDD. The Korean Society for Brain and Neural Sciences 2022-10-31 2022-10-31 /pmc/articles/PMC9659491/ /pubmed/36351844 http://dx.doi.org/10.5607/en22030 Text en Copyright © Experimental Neurobiology 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kang, Youbin
Kim, Aram
Kang, Wooyoung
Han, Kyu-Man
Ham, Byoungjoo
The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder
title The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder
title_full The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder
title_fullStr The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder
title_full_unstemmed The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder
title_short The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder
title_sort association of white matter tracts with alexithymia among individuals with major depressive disorder
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659491/
https://www.ncbi.nlm.nih.gov/pubmed/36351844
http://dx.doi.org/10.5607/en22030
work_keys_str_mv AT kangyoubin theassociationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT kimaram theassociationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT kangwooyoung theassociationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT hankyuman theassociationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT hambyoungjoo theassociationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT kangyoubin associationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT kimaram associationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT kangwooyoung associationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT hankyuman associationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder
AT hambyoungjoo associationofwhitemattertractswithalexithymiaamongindividualswithmajordepressivedisorder