Risk Factors of Osteoporosis in Females: A Hospital-Based Case-Control Study, Yazd, Iran

BACKGROUND: The aim of this study was to evaluate the predictors of osteoporosis in women in Yazd, Iran. METHODS: This hospital-based case-control study was performed on 270 women 35–65 yr old (135 case and 135 control) from Mar 2016 to Mar 2017. Case and control were matched in terms of age ± 2 (year) as a group matching. Osteoporosis is defined as a T-score of bone mineral density (BMD) below −2.5 SD. Data were analyzed using SPSS 20 software. Statistical tests included chi-square, student t test and Mann Whitney test .Multiple logistic regression (MLR) which forward method was used for modeling. RESULTS: Odds ratio (OR) of osteoprosis were menarche age>12 yr (OR=3.37, CI:2.29–15.89), history of hysterectomy (OR=13, CI:3.81–44.82), rheumatoid arthritis (RA) (OR=6.58, CI:2.29–18.91) calcium supplements (OR=0.14, CI:0.04–0.41), menopause age <40 (OR=11.84, CI:1.54–90), second smoking (OR=3.38, CI:1.16–9.81) and increase of weight (OR=0.86, CI:0.80–0.94). CONCLUSION: Predictors of osteoporosis was menarche age >12 yr (3 times), history of hysterectomy (13 times), RA (6.5 times), menopause age <40 (12 times), second smoking (more than 3 times), calcium supplements and weight (protective).