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A time-delayed model for the spread of COVID-19 with vaccination

A mathematical model is presented in this paper to investigate the effects of time delay in vaccine production on COVID-19 spread. The model is analyzed qualitatively and numerically. The qualitative analysis indicates that the system variables are non-negative, bounded, and biologically meaningful....

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Detalles Bibliográficos
Autores principales: Al-Tuwairqi, Salma M., Al-Harbi, Sara K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659561/
https://www.ncbi.nlm.nih.gov/pubmed/36372827
http://dx.doi.org/10.1038/s41598-022-23822-5
Descripción
Sumario:A mathematical model is presented in this paper to investigate the effects of time delay in vaccine production on COVID-19 spread. The model is analyzed qualitatively and numerically. The qualitative analysis indicates that the system variables are non-negative, bounded, and biologically meaningful. Moreover, the model has produced two equilibrium points: the free equilibrium point, which can exist without conditions, and the endemic equilibrium point, which can exist if the control reproduction number, [Formula: see text] , is not less than one. In addition, the local stability of the equilibrium points is investigated and agrees with the numerical analysis results. Finally, a sensitivity analysis is conducted for [Formula: see text] . In particular, we examine the effect of the vaccine’s time delay, vaccine rate, and vaccine efficiency on the model dynamics.