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A time-delayed model for the spread of COVID-19 with vaccination
A mathematical model is presented in this paper to investigate the effects of time delay in vaccine production on COVID-19 spread. The model is analyzed qualitatively and numerically. The qualitative analysis indicates that the system variables are non-negative, bounded, and biologically meaningful....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659561/ https://www.ncbi.nlm.nih.gov/pubmed/36372827 http://dx.doi.org/10.1038/s41598-022-23822-5 |
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author | Al-Tuwairqi, Salma M. Al-Harbi, Sara K. |
author_facet | Al-Tuwairqi, Salma M. Al-Harbi, Sara K. |
author_sort | Al-Tuwairqi, Salma M. |
collection | PubMed |
description | A mathematical model is presented in this paper to investigate the effects of time delay in vaccine production on COVID-19 spread. The model is analyzed qualitatively and numerically. The qualitative analysis indicates that the system variables are non-negative, bounded, and biologically meaningful. Moreover, the model has produced two equilibrium points: the free equilibrium point, which can exist without conditions, and the endemic equilibrium point, which can exist if the control reproduction number, [Formula: see text] , is not less than one. In addition, the local stability of the equilibrium points is investigated and agrees with the numerical analysis results. Finally, a sensitivity analysis is conducted for [Formula: see text] . In particular, we examine the effect of the vaccine’s time delay, vaccine rate, and vaccine efficiency on the model dynamics. |
format | Online Article Text |
id | pubmed-9659561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96595612022-11-14 A time-delayed model for the spread of COVID-19 with vaccination Al-Tuwairqi, Salma M. Al-Harbi, Sara K. Sci Rep Article A mathematical model is presented in this paper to investigate the effects of time delay in vaccine production on COVID-19 spread. The model is analyzed qualitatively and numerically. The qualitative analysis indicates that the system variables are non-negative, bounded, and biologically meaningful. Moreover, the model has produced two equilibrium points: the free equilibrium point, which can exist without conditions, and the endemic equilibrium point, which can exist if the control reproduction number, [Formula: see text] , is not less than one. In addition, the local stability of the equilibrium points is investigated and agrees with the numerical analysis results. Finally, a sensitivity analysis is conducted for [Formula: see text] . In particular, we examine the effect of the vaccine’s time delay, vaccine rate, and vaccine efficiency on the model dynamics. Nature Publishing Group UK 2022-11-13 /pmc/articles/PMC9659561/ /pubmed/36372827 http://dx.doi.org/10.1038/s41598-022-23822-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Al-Tuwairqi, Salma M. Al-Harbi, Sara K. A time-delayed model for the spread of COVID-19 with vaccination |
title | A time-delayed model for the spread of COVID-19 with vaccination |
title_full | A time-delayed model for the spread of COVID-19 with vaccination |
title_fullStr | A time-delayed model for the spread of COVID-19 with vaccination |
title_full_unstemmed | A time-delayed model for the spread of COVID-19 with vaccination |
title_short | A time-delayed model for the spread of COVID-19 with vaccination |
title_sort | time-delayed model for the spread of covid-19 with vaccination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659561/ https://www.ncbi.nlm.nih.gov/pubmed/36372827 http://dx.doi.org/10.1038/s41598-022-23822-5 |
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