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Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials
Vitamin D supplementation and its impact on immunoregulation are widely investigated. We aimed to assess the prevention and treatment efficiency of vitamin D supplementation in the context of coronavirus disease 2019 (COVID-19) and any disease-related complications. For this systematic review and me...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659578/ https://www.ncbi.nlm.nih.gov/pubmed/36389703 http://dx.doi.org/10.3389/fimmu.2022.1023903 |
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author | Kümmel, Lara S. Krumbein, Hanna Fragkou, Paraskevi C. Hünerbein, Ben L. Reiter, Rieke Papathanasiou, Konstantinos A. Thölken, Clemens Weiss, Scott T. Renz, Harald Skevaki, Chrysanthi |
author_facet | Kümmel, Lara S. Krumbein, Hanna Fragkou, Paraskevi C. Hünerbein, Ben L. Reiter, Rieke Papathanasiou, Konstantinos A. Thölken, Clemens Weiss, Scott T. Renz, Harald Skevaki, Chrysanthi |
author_sort | Kümmel, Lara S. |
collection | PubMed |
description | Vitamin D supplementation and its impact on immunoregulation are widely investigated. We aimed to assess the prevention and treatment efficiency of vitamin D supplementation in the context of coronavirus disease 2019 (COVID-19) and any disease-related complications. For this systematic review and meta-analysis, we searched databases (PubMed, Embase, Scopus, Web of Science, The Cochrane Library, medRxiv, Cochrane COVID-19 Study Register, and ClinicalTrial.gov) for studies published between 1 November 2019 and 17 September 2021. We considered randomized trials (RCTs) as potentially eligible when patients were tested for SARS-CoV-2 infection and received vitamin D supplementation versus a placebo or standard-of-care control. A random-effects model was implemented to obtain pooled odds ratios for the effect of vitamin D supplementation on the main outcome of mortality as well as clinical outcomes. We identified a total of 5,733 articles, of which eight RCTs (657 patients) met the eligibility criteria. Although no statistically significant effects were reached, the use of vitamin D supplementation showed a trend for reduced mortality [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.32–1.71, p = 0.48] compared with the control group, with even stronger effects, when vitamin D was administered repeatedly (OR 0.33, 95% CI 0.1–1.14). The mean difference for the length of hospitalization was −0.28 (95% CI −0.60 to 0.04), and the ORs were 0.41 (95% CI 0.15–1.12) and 0.52 (95% CI 0.27–1.02) for ICU admission and mechanical ventilation, respectively. In conclusion, vitamin D supplementation did not improve the clinical outcomes in COVID-19 patients, but trends of beneficial effects were observed. Further investigations are required, especially studies focusing on the daily administration of vitamin D. |
format | Online Article Text |
id | pubmed-9659578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96595782022-11-15 Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials Kümmel, Lara S. Krumbein, Hanna Fragkou, Paraskevi C. Hünerbein, Ben L. Reiter, Rieke Papathanasiou, Konstantinos A. Thölken, Clemens Weiss, Scott T. Renz, Harald Skevaki, Chrysanthi Front Immunol Immunology Vitamin D supplementation and its impact on immunoregulation are widely investigated. We aimed to assess the prevention and treatment efficiency of vitamin D supplementation in the context of coronavirus disease 2019 (COVID-19) and any disease-related complications. For this systematic review and meta-analysis, we searched databases (PubMed, Embase, Scopus, Web of Science, The Cochrane Library, medRxiv, Cochrane COVID-19 Study Register, and ClinicalTrial.gov) for studies published between 1 November 2019 and 17 September 2021. We considered randomized trials (RCTs) as potentially eligible when patients were tested for SARS-CoV-2 infection and received vitamin D supplementation versus a placebo or standard-of-care control. A random-effects model was implemented to obtain pooled odds ratios for the effect of vitamin D supplementation on the main outcome of mortality as well as clinical outcomes. We identified a total of 5,733 articles, of which eight RCTs (657 patients) met the eligibility criteria. Although no statistically significant effects were reached, the use of vitamin D supplementation showed a trend for reduced mortality [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.32–1.71, p = 0.48] compared with the control group, with even stronger effects, when vitamin D was administered repeatedly (OR 0.33, 95% CI 0.1–1.14). The mean difference for the length of hospitalization was −0.28 (95% CI −0.60 to 0.04), and the ORs were 0.41 (95% CI 0.15–1.12) and 0.52 (95% CI 0.27–1.02) for ICU admission and mechanical ventilation, respectively. In conclusion, vitamin D supplementation did not improve the clinical outcomes in COVID-19 patients, but trends of beneficial effects were observed. Further investigations are required, especially studies focusing on the daily administration of vitamin D. Frontiers Media S.A. 2022-10-31 /pmc/articles/PMC9659578/ /pubmed/36389703 http://dx.doi.org/10.3389/fimmu.2022.1023903 Text en Copyright © 2022 Kümmel, Krumbein, Fragkou, Hünerbein, Reiter, Papathanasiou, Thölken, Weiss, Renz and Skevaki https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kümmel, Lara S. Krumbein, Hanna Fragkou, Paraskevi C. Hünerbein, Ben L. Reiter, Rieke Papathanasiou, Konstantinos A. Thölken, Clemens Weiss, Scott T. Renz, Harald Skevaki, Chrysanthi Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
title | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
title_full | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
title_fullStr | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
title_full_unstemmed | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
title_short | Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials |
title_sort | vitamin d supplementation for the treatment of covid-19: a systematic review and meta-analysis of randomized controlled trials |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659578/ https://www.ncbi.nlm.nih.gov/pubmed/36389703 http://dx.doi.org/10.3389/fimmu.2022.1023903 |
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