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Case report and literature review: Rare male aggressive angiomyxoma of the scrotum

Aggressive angiomyxoma (AAM) is an uncommon locally infiltrative tumor that frequently occurs in the pelvic soft tissues of female patients; it has a high rate of local recurrence. However, AAM is extremely rare in males. Herein, we present the case of a 70-year-old man with a gradually enlarging pa...

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Autores principales: Chen, Yue, Wei, YaPing, Chang, Hong, Yu, ChunKai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659604/
https://www.ncbi.nlm.nih.gov/pubmed/36386525
http://dx.doi.org/10.3389/fsurg.2022.955655
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author Chen, Yue
Wei, YaPing
Chang, Hong
Yu, ChunKai
author_facet Chen, Yue
Wei, YaPing
Chang, Hong
Yu, ChunKai
author_sort Chen, Yue
collection PubMed
description Aggressive angiomyxoma (AAM) is an uncommon locally infiltrative tumor that frequently occurs in the pelvic soft tissues of female patients; it has a high rate of local recurrence. However, AAM is extremely rare in males. Herein, we present the case of a 70-year-old man with a gradually enlarging painless mass in the scrotum. The patient underwent local excision of the scrotal AAM, with no local relapse after 17 months of follow-up. In addition to the present case, the clinicopathological features of males with AAM reported in literature (to the best of our knowledge) are discussed in this report. The literature review revealed that the gross morphology, clinical process, and histopathology of AAM in males resemble those of AAM in females. In particular, estrogen receptor/progesterone receptor has been shown to be expressed in male patients, which may provide an option for hormone therapy. Moreover, in males, a lower recurrence rate has been observed after surgery to remove the tumor. However, more data are needed to validate this observation. This report emphasizes the importance of considering AAM as the differential diagnosis of myxoid neoplasms in male genital areas.
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spelling pubmed-96596042022-11-15 Case report and literature review: Rare male aggressive angiomyxoma of the scrotum Chen, Yue Wei, YaPing Chang, Hong Yu, ChunKai Front Surg Surgery Aggressive angiomyxoma (AAM) is an uncommon locally infiltrative tumor that frequently occurs in the pelvic soft tissues of female patients; it has a high rate of local recurrence. However, AAM is extremely rare in males. Herein, we present the case of a 70-year-old man with a gradually enlarging painless mass in the scrotum. The patient underwent local excision of the scrotal AAM, with no local relapse after 17 months of follow-up. In addition to the present case, the clinicopathological features of males with AAM reported in literature (to the best of our knowledge) are discussed in this report. The literature review revealed that the gross morphology, clinical process, and histopathology of AAM in males resemble those of AAM in females. In particular, estrogen receptor/progesterone receptor has been shown to be expressed in male patients, which may provide an option for hormone therapy. Moreover, in males, a lower recurrence rate has been observed after surgery to remove the tumor. However, more data are needed to validate this observation. This report emphasizes the importance of considering AAM as the differential diagnosis of myxoid neoplasms in male genital areas. Frontiers Media S.A. 2022-10-31 /pmc/articles/PMC9659604/ /pubmed/36386525 http://dx.doi.org/10.3389/fsurg.2022.955655 Text en © 2022 Chen, Wei, Chang and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Chen, Yue
Wei, YaPing
Chang, Hong
Yu, ChunKai
Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
title Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
title_full Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
title_fullStr Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
title_full_unstemmed Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
title_short Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
title_sort case report and literature review: rare male aggressive angiomyxoma of the scrotum
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659604/
https://www.ncbi.nlm.nih.gov/pubmed/36386525
http://dx.doi.org/10.3389/fsurg.2022.955655
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