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Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?

Lipedema may be considered a model for healthy expandability of subcutaneous adipose tissue (SAT). This condition is characterized by the disproportional and symmetrical SAT accumulation in the lower-body parts and extremities, avoiding the abdominal area. There are no circulating biomarkers facilit...

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Autores principales: Nankam, Pamela A. Nono, Cornely, Manuel, Klöting, Nora, Blüher, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659629/
https://www.ncbi.nlm.nih.gov/pubmed/36387874
http://dx.doi.org/10.3389/fendo.2022.1000094
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author Nankam, Pamela A. Nono
Cornely, Manuel
Klöting, Nora
Blüher, Matthias
author_facet Nankam, Pamela A. Nono
Cornely, Manuel
Klöting, Nora
Blüher, Matthias
author_sort Nankam, Pamela A. Nono
collection PubMed
description Lipedema may be considered a model for healthy expandability of subcutaneous adipose tissue (SAT). This condition is characterized by the disproportional and symmetrical SAT accumulation in the lower-body parts and extremities, avoiding the abdominal area. There are no circulating biomarkers facilitating the diagnosis of lipedema. We tested the hypothesis that women living with lipedema present a distinct pattern of circulating parameters compared to age- and BMI-matched women. In 26 women (Age 48.3 ± 13.9 years, BMI 32.6 ± 5.8 kg/m2; lipedema group: n=13; control group: n=13), we assessed circulating parameters of glucose and lipid metabolism, inflammation, oxidative stress, sex hormones and a proteomics panel. We find that women with lipedema have better glucose metabolism regulation represented by lower HbA1c (5.55 ± 0.62%) compared to controls (6.73 ± 0.85%; p<0.001); and higher adiponectin levels (lipedema: 4.69 ± 1.99 mmol/l; control: 3.28 ± 1.00 mmol/l; p=0.038). Despite normal glycemic parameters, women with lipedema have significantly higher levels of total cholesterol (5.84 ± 0.70 mmol/L vs 4.55 ± 0.77 mmol/L in control; p<0.001), LDL-C (3.38 ± 0.68 mmol/L vs 2.38 ± 0.66 mmol/L in control; p=0.002), as well as higher circulating inflammation (top 6 based on p-values: TNFSF14, CASP8, EN-RAGE, EIF4EBP1, ADA, MCP-1) and oxidative stress markers (malondialdehyde, superoxide dismutase and catalase). Our findings suggest that the expected association between activation of inflammatory and oxidative stress pathways and impaired glucose metabolism are counterbalanced by protective factors in lipedema.
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spelling pubmed-96596292022-11-15 Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters? Nankam, Pamela A. Nono Cornely, Manuel Klöting, Nora Blüher, Matthias Front Endocrinol (Lausanne) Endocrinology Lipedema may be considered a model for healthy expandability of subcutaneous adipose tissue (SAT). This condition is characterized by the disproportional and symmetrical SAT accumulation in the lower-body parts and extremities, avoiding the abdominal area. There are no circulating biomarkers facilitating the diagnosis of lipedema. We tested the hypothesis that women living with lipedema present a distinct pattern of circulating parameters compared to age- and BMI-matched women. In 26 women (Age 48.3 ± 13.9 years, BMI 32.6 ± 5.8 kg/m2; lipedema group: n=13; control group: n=13), we assessed circulating parameters of glucose and lipid metabolism, inflammation, oxidative stress, sex hormones and a proteomics panel. We find that women with lipedema have better glucose metabolism regulation represented by lower HbA1c (5.55 ± 0.62%) compared to controls (6.73 ± 0.85%; p<0.001); and higher adiponectin levels (lipedema: 4.69 ± 1.99 mmol/l; control: 3.28 ± 1.00 mmol/l; p=0.038). Despite normal glycemic parameters, women with lipedema have significantly higher levels of total cholesterol (5.84 ± 0.70 mmol/L vs 4.55 ± 0.77 mmol/L in control; p<0.001), LDL-C (3.38 ± 0.68 mmol/L vs 2.38 ± 0.66 mmol/L in control; p=0.002), as well as higher circulating inflammation (top 6 based on p-values: TNFSF14, CASP8, EN-RAGE, EIF4EBP1, ADA, MCP-1) and oxidative stress markers (malondialdehyde, superoxide dismutase and catalase). Our findings suggest that the expected association between activation of inflammatory and oxidative stress pathways and impaired glucose metabolism are counterbalanced by protective factors in lipedema. Frontiers Media S.A. 2022-10-31 /pmc/articles/PMC9659629/ /pubmed/36387874 http://dx.doi.org/10.3389/fendo.2022.1000094 Text en Copyright © 2022 Nankam, Cornely, Klöting and Blüher https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Nankam, Pamela A. Nono
Cornely, Manuel
Klöting, Nora
Blüher, Matthias
Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
title Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
title_full Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
title_fullStr Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
title_full_unstemmed Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
title_short Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
title_sort is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659629/
https://www.ncbi.nlm.nih.gov/pubmed/36387874
http://dx.doi.org/10.3389/fendo.2022.1000094
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