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Relationship between sleep disorders and the prognosis of neurological function after stroke

OBJECTIVE: This study aims to investigate the effects of sleep disorders on the prognosis of neurological function after stroke and other factors affecting the prognosis after stroke. METHOD: We designed a cohort study. A total of 1,542 patients with their first stroke were hospitalized in the depar...

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Autores principales: Zhang, Yajing, Xia, Xiaoshuang, Zhang, Ting, Zhang, Chao, Liu, Ran, Yang, Yun, Liu, Shuling, Li, Xin, Yue, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659634/
https://www.ncbi.nlm.nih.gov/pubmed/36388217
http://dx.doi.org/10.3389/fneur.2022.1036980
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author Zhang, Yajing
Xia, Xiaoshuang
Zhang, Ting
Zhang, Chao
Liu, Ran
Yang, Yun
Liu, Shuling
Li, Xin
Yue, Wei
author_facet Zhang, Yajing
Xia, Xiaoshuang
Zhang, Ting
Zhang, Chao
Liu, Ran
Yang, Yun
Liu, Shuling
Li, Xin
Yue, Wei
author_sort Zhang, Yajing
collection PubMed
description OBJECTIVE: This study aims to investigate the effects of sleep disorders on the prognosis of neurological function after stroke and other factors affecting the prognosis after stroke. METHOD: We designed a cohort study. A total of 1,542 patients with their first stroke were hospitalized in the department of neurology of Tianjin Huanhu Hospital from 2015.6.1 to 2016.12.31. We recorded the personal histories of patients. The MMSE (mini-mental state examination), MoCA (Montreal Cognitive Assessment), HAMD (Hamilton Depression Scale), National Institutes of Health Stroke Scale (NIHSS) score, mRS (Modified Rankin Scale), BI (Barthel Index), PSQI (Pittsburgh Sleep Quality Index), ESS (Epworth Sleepiness Scale), Berlin questionnaire, and nocturnal TST (Total sleep time) were assessed before discharge, 3 months, 6 months, and 4 years (2019–2020) after stroke. RESULT: Low sleep quality (OR 2.019, 95%CI 1.199–3.398, p = 0.008), nocturnal TST (<7 h) (OR 4.060, 95%CI 1.494–11.034, p = 0.006), nocturnal TST (>8 h) (OR 5.928, 95% CI 2.134–16.464, p = 0.001) were risk factors for poor neurological function recovery at 3 months after stroke. Nocturnal TST (<7 h) (OR 13.042, 95%-CI 2.576–66.027, p = 0.002) and nocturnal TST (>8 h) (OR 11.559, 95%-CI 2.108–63.390, p = 0.005) were risk factors for poor neurological function at 6 months after stroke. Nocturnal TST (<7 h) (OR 2.668, 95% CI 1.250–5.698, p = 0.011) and nocturnal TST (>8 h) (OR 2.516, 95% CI 1.080–5.861, p = 0.033) were risk factors for poor neurological function at 4 years after stroke. High risk of OSA (HR 1.582, 95%CI 1.244–2.012, p < 0.001) was a risk factor for all-cause death in patients followed up for 4 years after stroke. CONCLUSION: Low sleep quality is associated with short-term poor neurological function after stroke. Unusual nocturnal TST (long or short) is associated with short-term or long-term poor neurological function after stroke. A high risk of OSA is associated with a higher risk of all-cause death after stroke.
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spelling pubmed-96596342022-11-15 Relationship between sleep disorders and the prognosis of neurological function after stroke Zhang, Yajing Xia, Xiaoshuang Zhang, Ting Zhang, Chao Liu, Ran Yang, Yun Liu, Shuling Li, Xin Yue, Wei Front Neurol Neurology OBJECTIVE: This study aims to investigate the effects of sleep disorders on the prognosis of neurological function after stroke and other factors affecting the prognosis after stroke. METHOD: We designed a cohort study. A total of 1,542 patients with their first stroke were hospitalized in the department of neurology of Tianjin Huanhu Hospital from 2015.6.1 to 2016.12.31. We recorded the personal histories of patients. The MMSE (mini-mental state examination), MoCA (Montreal Cognitive Assessment), HAMD (Hamilton Depression Scale), National Institutes of Health Stroke Scale (NIHSS) score, mRS (Modified Rankin Scale), BI (Barthel Index), PSQI (Pittsburgh Sleep Quality Index), ESS (Epworth Sleepiness Scale), Berlin questionnaire, and nocturnal TST (Total sleep time) were assessed before discharge, 3 months, 6 months, and 4 years (2019–2020) after stroke. RESULT: Low sleep quality (OR 2.019, 95%CI 1.199–3.398, p = 0.008), nocturnal TST (<7 h) (OR 4.060, 95%CI 1.494–11.034, p = 0.006), nocturnal TST (>8 h) (OR 5.928, 95% CI 2.134–16.464, p = 0.001) were risk factors for poor neurological function recovery at 3 months after stroke. Nocturnal TST (<7 h) (OR 13.042, 95%-CI 2.576–66.027, p = 0.002) and nocturnal TST (>8 h) (OR 11.559, 95%-CI 2.108–63.390, p = 0.005) were risk factors for poor neurological function at 6 months after stroke. Nocturnal TST (<7 h) (OR 2.668, 95% CI 1.250–5.698, p = 0.011) and nocturnal TST (>8 h) (OR 2.516, 95% CI 1.080–5.861, p = 0.033) were risk factors for poor neurological function at 4 years after stroke. High risk of OSA (HR 1.582, 95%CI 1.244–2.012, p < 0.001) was a risk factor for all-cause death in patients followed up for 4 years after stroke. CONCLUSION: Low sleep quality is associated with short-term poor neurological function after stroke. Unusual nocturnal TST (long or short) is associated with short-term or long-term poor neurological function after stroke. A high risk of OSA is associated with a higher risk of all-cause death after stroke. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9659634/ /pubmed/36388217 http://dx.doi.org/10.3389/fneur.2022.1036980 Text en Copyright © 2022 Zhang, Xia, Zhang, Zhang, Liu, Yang, Liu, Li and Yue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhang, Yajing
Xia, Xiaoshuang
Zhang, Ting
Zhang, Chao
Liu, Ran
Yang, Yun
Liu, Shuling
Li, Xin
Yue, Wei
Relationship between sleep disorders and the prognosis of neurological function after stroke
title Relationship between sleep disorders and the prognosis of neurological function after stroke
title_full Relationship between sleep disorders and the prognosis of neurological function after stroke
title_fullStr Relationship between sleep disorders and the prognosis of neurological function after stroke
title_full_unstemmed Relationship between sleep disorders and the prognosis of neurological function after stroke
title_short Relationship between sleep disorders and the prognosis of neurological function after stroke
title_sort relationship between sleep disorders and the prognosis of neurological function after stroke
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659634/
https://www.ncbi.nlm.nih.gov/pubmed/36388217
http://dx.doi.org/10.3389/fneur.2022.1036980
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