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The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

BACKGROUND: Obesity‐induced inflammation may independently disturb the function of critical organs such as liver. This study aimed to investigate the association of obesity with serum levels of biomarkers of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), a...

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Autores principales: Jalili, Vahideh, Poorahmadi, Zohreh, Hasanpour Ardekanizadeh, Naeemeh, Gholamalizadeh, Maryam, Ajami, Marjan, Houshiarrad, Anahita, Hajipour, Azadeh, Shafie, Fatemeh, Alizadeh, Atiyeh, Mokhtari, Zohreh, Shafaei, Hanieh, Esmaeili, Mina, Doaei, Saeid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659656/
https://www.ncbi.nlm.nih.gov/pubmed/36039792
http://dx.doi.org/10.1002/edm2.367
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author Jalili, Vahideh
Poorahmadi, Zohreh
Hasanpour Ardekanizadeh, Naeemeh
Gholamalizadeh, Maryam
Ajami, Marjan
Houshiarrad, Anahita
Hajipour, Azadeh
Shafie, Fatemeh
Alizadeh, Atiyeh
Mokhtari, Zohreh
Shafaei, Hanieh
Esmaeili, Mina
Doaei, Saeid
author_facet Jalili, Vahideh
Poorahmadi, Zohreh
Hasanpour Ardekanizadeh, Naeemeh
Gholamalizadeh, Maryam
Ajami, Marjan
Houshiarrad, Anahita
Hajipour, Azadeh
Shafie, Fatemeh
Alizadeh, Atiyeh
Mokhtari, Zohreh
Shafaei, Hanieh
Esmaeili, Mina
Doaei, Saeid
author_sort Jalili, Vahideh
collection PubMed
description BACKGROUND: Obesity‐induced inflammation may independently disturb the function of critical organs such as liver. This study aimed to investigate the association of obesity with serum levels of biomarkers of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma‐glutamyl transferase (GGT) in adult women. METHODS: This cross‐sectional study was carried out on 360 adult women in the summer of 2020 in Tehran, Iran. The participants were categorized into two groups based on their body mass index (BMI≤29.9 and BMI > 30). The serum levels of ALT, AST, ALP and GGT were measured. Logistic regression method was used to assess the association between BMI and liver enzymes after adjusting for the confounders. RESULTS: The mean BMI in non‐obese and obese groups was 26.32 ± 2.61 and 33.40 ± 2.80 kg/m(2), respectively (p = .01). A significant association was found between BMI with ALT (β = .16, p = .002) and GGT (β = .19, p = .01) enzymes after adjustment for age. The association between BMI and GGT remained significant after further adjustments for smoking, alcohol use, physical activity and educational status. There was no significant association between BMI and liver enzymes after adjustment for dietary intake. CONCLUSIONS: Obesity was associated with the level of serum liver enzymes. However, adjustment for dietary intake disappeared the significant results. Further studies are needed to determine the independent effects of obesity on the liver function.
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spelling pubmed-96596562022-11-14 The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women Jalili, Vahideh Poorahmadi, Zohreh Hasanpour Ardekanizadeh, Naeemeh Gholamalizadeh, Maryam Ajami, Marjan Houshiarrad, Anahita Hajipour, Azadeh Shafie, Fatemeh Alizadeh, Atiyeh Mokhtari, Zohreh Shafaei, Hanieh Esmaeili, Mina Doaei, Saeid Endocrinol Diabetes Metab Research Articles BACKGROUND: Obesity‐induced inflammation may independently disturb the function of critical organs such as liver. This study aimed to investigate the association of obesity with serum levels of biomarkers of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma‐glutamyl transferase (GGT) in adult women. METHODS: This cross‐sectional study was carried out on 360 adult women in the summer of 2020 in Tehran, Iran. The participants were categorized into two groups based on their body mass index (BMI≤29.9 and BMI > 30). The serum levels of ALT, AST, ALP and GGT were measured. Logistic regression method was used to assess the association between BMI and liver enzymes after adjusting for the confounders. RESULTS: The mean BMI in non‐obese and obese groups was 26.32 ± 2.61 and 33.40 ± 2.80 kg/m(2), respectively (p = .01). A significant association was found between BMI with ALT (β = .16, p = .002) and GGT (β = .19, p = .01) enzymes after adjustment for age. The association between BMI and GGT remained significant after further adjustments for smoking, alcohol use, physical activity and educational status. There was no significant association between BMI and liver enzymes after adjustment for dietary intake. CONCLUSIONS: Obesity was associated with the level of serum liver enzymes. However, adjustment for dietary intake disappeared the significant results. Further studies are needed to determine the independent effects of obesity on the liver function. John Wiley and Sons Inc. 2022-08-30 /pmc/articles/PMC9659656/ /pubmed/36039792 http://dx.doi.org/10.1002/edm2.367 Text en © 2022 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Jalili, Vahideh
Poorahmadi, Zohreh
Hasanpour Ardekanizadeh, Naeemeh
Gholamalizadeh, Maryam
Ajami, Marjan
Houshiarrad, Anahita
Hajipour, Azadeh
Shafie, Fatemeh
Alizadeh, Atiyeh
Mokhtari, Zohreh
Shafaei, Hanieh
Esmaeili, Mina
Doaei, Saeid
The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
title The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
title_full The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
title_fullStr The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
title_full_unstemmed The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
title_short The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
title_sort association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659656/
https://www.ncbi.nlm.nih.gov/pubmed/36039792
http://dx.doi.org/10.1002/edm2.367
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