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Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659759/ https://www.ncbi.nlm.nih.gov/pubmed/36389831 http://dx.doi.org/10.3389/fimmu.2022.1049368 |
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author | Pinto, Ana Carolina Matias Dinelly Nunes, Rodolfo de Melo Nogueira, Igor Albuquerque Fischer, Bernhard Lucas, Rudolf Girão-Carmona, Virgínia Claudia Carneiro de Oliveira, Vivian Louise Soares Amaral, Flavio Almeida Schett, Georg Rocha, Francisco Airton Castro |
author_facet | Pinto, Ana Carolina Matias Dinelly Nunes, Rodolfo de Melo Nogueira, Igor Albuquerque Fischer, Bernhard Lucas, Rudolf Girão-Carmona, Virgínia Claudia Carneiro de Oliveira, Vivian Louise Soares Amaral, Flavio Almeida Schett, Georg Rocha, Francisco Airton Castro |
author_sort | Pinto, Ana Carolina Matias Dinelly |
collection | PubMed |
description | In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients achieve remission; moreover, there is a risk of increased susceptibility to infection with these agents. Spatially distinct from its receptor binding sites, TNF harbors a lectin-like domain, which exerts unique functions that can be mimicked by the 17 residue solnatide peptide. This domain binds to specific oligosaccharides such as N′N′-diacetylchitobiose and directly target the α subunit of the epithelial sodium channel. Solnatide was shown to have anti-inflammatory actions in acute lung injury and glomerulonephritis models. In this study, we evaluated whether the lectin-like domain of TNF can mitigate the development of immune-mediated arthritis in mice. In an antigen-induced arthritis model, solnatide reduced cell influx and release of pro-inflammatory mediators into the joints, associated with reduction in edema and tissue damage, as compared to controls indicating that TNF has anti-inflammatory effects in an acute model of joint inflammation via its lectin-like domain. |
format | Online Article Text |
id | pubmed-9659759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96597592022-11-15 Potent anti-inflammatory activity of the lectin-like domain of TNF in joints Pinto, Ana Carolina Matias Dinelly Nunes, Rodolfo de Melo Nogueira, Igor Albuquerque Fischer, Bernhard Lucas, Rudolf Girão-Carmona, Virgínia Claudia Carneiro de Oliveira, Vivian Louise Soares Amaral, Flavio Almeida Schett, Georg Rocha, Francisco Airton Castro Front Immunol Immunology In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients achieve remission; moreover, there is a risk of increased susceptibility to infection with these agents. Spatially distinct from its receptor binding sites, TNF harbors a lectin-like domain, which exerts unique functions that can be mimicked by the 17 residue solnatide peptide. This domain binds to specific oligosaccharides such as N′N′-diacetylchitobiose and directly target the α subunit of the epithelial sodium channel. Solnatide was shown to have anti-inflammatory actions in acute lung injury and glomerulonephritis models. In this study, we evaluated whether the lectin-like domain of TNF can mitigate the development of immune-mediated arthritis in mice. In an antigen-induced arthritis model, solnatide reduced cell influx and release of pro-inflammatory mediators into the joints, associated with reduction in edema and tissue damage, as compared to controls indicating that TNF has anti-inflammatory effects in an acute model of joint inflammation via its lectin-like domain. Frontiers Media S.A. 2022-10-31 /pmc/articles/PMC9659759/ /pubmed/36389831 http://dx.doi.org/10.3389/fimmu.2022.1049368 Text en Copyright © 2022 Pinto, Nunes, Nogueira, Fischer, Lucas, Girão-Carmona, de Oliveira, Amaral, Schett and Rocha https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Pinto, Ana Carolina Matias Dinelly Nunes, Rodolfo de Melo Nogueira, Igor Albuquerque Fischer, Bernhard Lucas, Rudolf Girão-Carmona, Virgínia Claudia Carneiro de Oliveira, Vivian Louise Soares Amaral, Flavio Almeida Schett, Georg Rocha, Francisco Airton Castro Potent anti-inflammatory activity of the lectin-like domain of TNF in joints |
title | Potent anti-inflammatory activity of the lectin-like domain of TNF in joints |
title_full | Potent anti-inflammatory activity of the lectin-like domain of TNF in joints |
title_fullStr | Potent anti-inflammatory activity of the lectin-like domain of TNF in joints |
title_full_unstemmed | Potent anti-inflammatory activity of the lectin-like domain of TNF in joints |
title_short | Potent anti-inflammatory activity of the lectin-like domain of TNF in joints |
title_sort | potent anti-inflammatory activity of the lectin-like domain of tnf in joints |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659759/ https://www.ncbi.nlm.nih.gov/pubmed/36389831 http://dx.doi.org/10.3389/fimmu.2022.1049368 |
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