Cargando…

Potent anti-inflammatory activity of the lectin-like domain of TNF in joints

In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinto, Ana Carolina Matias Dinelly, Nunes, Rodolfo de Melo, Nogueira, Igor Albuquerque, Fischer, Bernhard, Lucas, Rudolf, Girão-Carmona, Virgínia Claudia Carneiro, de Oliveira, Vivian Louise Soares, Amaral, Flavio Almeida, Schett, Georg, Rocha, Francisco Airton Castro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659759/
https://www.ncbi.nlm.nih.gov/pubmed/36389831
http://dx.doi.org/10.3389/fimmu.2022.1049368
_version_ 1784830268615426048
author Pinto, Ana Carolina Matias Dinelly
Nunes, Rodolfo de Melo
Nogueira, Igor Albuquerque
Fischer, Bernhard
Lucas, Rudolf
Girão-Carmona, Virgínia Claudia Carneiro
de Oliveira, Vivian Louise Soares
Amaral, Flavio Almeida
Schett, Georg
Rocha, Francisco Airton Castro
author_facet Pinto, Ana Carolina Matias Dinelly
Nunes, Rodolfo de Melo
Nogueira, Igor Albuquerque
Fischer, Bernhard
Lucas, Rudolf
Girão-Carmona, Virgínia Claudia Carneiro
de Oliveira, Vivian Louise Soares
Amaral, Flavio Almeida
Schett, Georg
Rocha, Francisco Airton Castro
author_sort Pinto, Ana Carolina Matias Dinelly
collection PubMed
description In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients achieve remission; moreover, there is a risk of increased susceptibility to infection with these agents. Spatially distinct from its receptor binding sites, TNF harbors a lectin-like domain, which exerts unique functions that can be mimicked by the 17 residue solnatide peptide. This domain binds to specific oligosaccharides such as N′N′-diacetylchitobiose and directly target the α subunit of the epithelial sodium channel. Solnatide was shown to have anti-inflammatory actions in acute lung injury and glomerulonephritis models. In this study, we evaluated whether the lectin-like domain of TNF can mitigate the development of immune-mediated arthritis in mice. In an antigen-induced arthritis model, solnatide reduced cell influx and release of pro-inflammatory mediators into the joints, associated with reduction in edema and tissue damage, as compared to controls indicating that TNF has anti-inflammatory effects in an acute model of joint inflammation via its lectin-like domain.
format Online
Article
Text
id pubmed-9659759
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96597592022-11-15 Potent anti-inflammatory activity of the lectin-like domain of TNF in joints Pinto, Ana Carolina Matias Dinelly Nunes, Rodolfo de Melo Nogueira, Igor Albuquerque Fischer, Bernhard Lucas, Rudolf Girão-Carmona, Virgínia Claudia Carneiro de Oliveira, Vivian Louise Soares Amaral, Flavio Almeida Schett, Georg Rocha, Francisco Airton Castro Front Immunol Immunology In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients achieve remission; moreover, there is a risk of increased susceptibility to infection with these agents. Spatially distinct from its receptor binding sites, TNF harbors a lectin-like domain, which exerts unique functions that can be mimicked by the 17 residue solnatide peptide. This domain binds to specific oligosaccharides such as N′N′-diacetylchitobiose and directly target the α subunit of the epithelial sodium channel. Solnatide was shown to have anti-inflammatory actions in acute lung injury and glomerulonephritis models. In this study, we evaluated whether the lectin-like domain of TNF can mitigate the development of immune-mediated arthritis in mice. In an antigen-induced arthritis model, solnatide reduced cell influx and release of pro-inflammatory mediators into the joints, associated with reduction in edema and tissue damage, as compared to controls indicating that TNF has anti-inflammatory effects in an acute model of joint inflammation via its lectin-like domain. Frontiers Media S.A. 2022-10-31 /pmc/articles/PMC9659759/ /pubmed/36389831 http://dx.doi.org/10.3389/fimmu.2022.1049368 Text en Copyright © 2022 Pinto, Nunes, Nogueira, Fischer, Lucas, Girão-Carmona, de Oliveira, Amaral, Schett and Rocha https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pinto, Ana Carolina Matias Dinelly
Nunes, Rodolfo de Melo
Nogueira, Igor Albuquerque
Fischer, Bernhard
Lucas, Rudolf
Girão-Carmona, Virgínia Claudia Carneiro
de Oliveira, Vivian Louise Soares
Amaral, Flavio Almeida
Schett, Georg
Rocha, Francisco Airton Castro
Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
title Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
title_full Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
title_fullStr Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
title_full_unstemmed Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
title_short Potent anti-inflammatory activity of the lectin-like domain of TNF in joints
title_sort potent anti-inflammatory activity of the lectin-like domain of tnf in joints
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659759/
https://www.ncbi.nlm.nih.gov/pubmed/36389831
http://dx.doi.org/10.3389/fimmu.2022.1049368
work_keys_str_mv AT pintoanacarolinamatiasdinelly potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT nunesrodolfodemelo potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT nogueiraigoralbuquerque potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT fischerbernhard potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT lucasrudolf potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT giraocarmonavirginiaclaudiacarneiro potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT deoliveiravivianlouisesoares potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT amaralflavioalmeida potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT schettgeorg potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints
AT rochafranciscoairtoncastro potentantiinflammatoryactivityofthelectinlikedomainoftnfinjoints