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Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months

OBJECTIVES: A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients. METHODS: COVID-19 pneumonia survivors (n = 317) were cate...

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Autores principales: de Roos, Marlise P, Siegerink, Sebastiaan, Dijkstra, Nynke G, Broekman, Birit FP, Brinkman, Kees, Jonkman, Nini H, Bresser, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659768/
https://www.ncbi.nlm.nih.gov/pubmed/36367295
http://dx.doi.org/10.1177/14799731221114271
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author de Roos, Marlise P
Siegerink, Sebastiaan
Dijkstra, Nynke G
Broekman, Birit FP
Brinkman, Kees
Jonkman, Nini H
Bresser, Paul
author_facet de Roos, Marlise P
Siegerink, Sebastiaan
Dijkstra, Nynke G
Broekman, Birit FP
Brinkman, Kees
Jonkman, Nini H
Bresser, Paul
author_sort de Roos, Marlise P
collection PubMed
description OBJECTIVES: A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients. METHODS: COVID-19 pneumonia survivors (n = 317) were categorized into non-hospitalized “moderate” cases (n = 59), hospitalized “severe” cases (n = 180) and ICU-admitted “critical” cases (n = 39). We studied DLCO and QoL (Short Form SF-36 health survey) 3 and 6 months after discharge. Data were analyzed using (repeated measures) ANOVA, Kruskal-Wallis or Chi-square test (p < .05). RESULTS: At 3 months DLCO was decreased in 44% of moderate-, 56% of severe- and 82% of critical cases (p < .003). Mean DLCO in critical cases (64±14%) was lower compared to severe (76 ± 17%) and moderate (81±15%) cases (p < .001). A total of 159/278 patients had a decreased DLCO (<80%), of whom the DLCO improved after 6 months in 45% (71/159). However the DLCO did not normalize in the majority (89%) of the cases (63 ± 10% vs 68±10%; p < .001). At 3 months, compared to critical cases, moderate cases scored lower on SF-36 domain “general health” (p < .05); both moderate and severe cases scored lower on the domain of “health change” (p < .05). At 6 months, there were no differences in SF-36 between the subgroups. Compared to 3 months, in all groups “physical functioning” improved; in contrast all groups scored significantly lower on “non-physical” SF-36 domains. CONCLUSION: Three months after COVID-19 pneumonia, DLCO was still decreased in the more severely affected patients, with an incomplete recovery after 6 months. At 3 months QoL was impaired. At 6 months, while “physical functioning” improved, a decrease in “non-physical” QoL was observed but did not differ between the moderate and severely affected patients.
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spelling pubmed-96597682022-11-15 Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months de Roos, Marlise P Siegerink, Sebastiaan Dijkstra, Nynke G Broekman, Birit FP Brinkman, Kees Jonkman, Nini H Bresser, Paul Chron Respir Dis Original Paper OBJECTIVES: A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients. METHODS: COVID-19 pneumonia survivors (n = 317) were categorized into non-hospitalized “moderate” cases (n = 59), hospitalized “severe” cases (n = 180) and ICU-admitted “critical” cases (n = 39). We studied DLCO and QoL (Short Form SF-36 health survey) 3 and 6 months after discharge. Data were analyzed using (repeated measures) ANOVA, Kruskal-Wallis or Chi-square test (p < .05). RESULTS: At 3 months DLCO was decreased in 44% of moderate-, 56% of severe- and 82% of critical cases (p < .003). Mean DLCO in critical cases (64±14%) was lower compared to severe (76 ± 17%) and moderate (81±15%) cases (p < .001). A total of 159/278 patients had a decreased DLCO (<80%), of whom the DLCO improved after 6 months in 45% (71/159). However the DLCO did not normalize in the majority (89%) of the cases (63 ± 10% vs 68±10%; p < .001). At 3 months, compared to critical cases, moderate cases scored lower on SF-36 domain “general health” (p < .05); both moderate and severe cases scored lower on the domain of “health change” (p < .05). At 6 months, there were no differences in SF-36 between the subgroups. Compared to 3 months, in all groups “physical functioning” improved; in contrast all groups scored significantly lower on “non-physical” SF-36 domains. CONCLUSION: Three months after COVID-19 pneumonia, DLCO was still decreased in the more severely affected patients, with an incomplete recovery after 6 months. At 3 months QoL was impaired. At 6 months, while “physical functioning” improved, a decrease in “non-physical” QoL was observed but did not differ between the moderate and severely affected patients. SAGE Publications 2022-11-11 /pmc/articles/PMC9659768/ /pubmed/36367295 http://dx.doi.org/10.1177/14799731221114271 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Paper
de Roos, Marlise P
Siegerink, Sebastiaan
Dijkstra, Nynke G
Broekman, Birit FP
Brinkman, Kees
Jonkman, Nini H
Bresser, Paul
Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
title Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
title_full Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
title_fullStr Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
title_full_unstemmed Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
title_short Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
title_sort pulmonary function and quality of life in a prospective cohort of (non-) hospitalized covid-19 pneumonia survivors up to six months
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659768/
https://www.ncbi.nlm.nih.gov/pubmed/36367295
http://dx.doi.org/10.1177/14799731221114271
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