Cargando…
Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months
OBJECTIVES: A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients. METHODS: COVID-19 pneumonia survivors (n = 317) were cate...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659768/ https://www.ncbi.nlm.nih.gov/pubmed/36367295 http://dx.doi.org/10.1177/14799731221114271 |
_version_ | 1784830270812192768 |
---|---|
author | de Roos, Marlise P Siegerink, Sebastiaan Dijkstra, Nynke G Broekman, Birit FP Brinkman, Kees Jonkman, Nini H Bresser, Paul |
author_facet | de Roos, Marlise P Siegerink, Sebastiaan Dijkstra, Nynke G Broekman, Birit FP Brinkman, Kees Jonkman, Nini H Bresser, Paul |
author_sort | de Roos, Marlise P |
collection | PubMed |
description | OBJECTIVES: A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients. METHODS: COVID-19 pneumonia survivors (n = 317) were categorized into non-hospitalized “moderate” cases (n = 59), hospitalized “severe” cases (n = 180) and ICU-admitted “critical” cases (n = 39). We studied DLCO and QoL (Short Form SF-36 health survey) 3 and 6 months after discharge. Data were analyzed using (repeated measures) ANOVA, Kruskal-Wallis or Chi-square test (p < .05). RESULTS: At 3 months DLCO was decreased in 44% of moderate-, 56% of severe- and 82% of critical cases (p < .003). Mean DLCO in critical cases (64±14%) was lower compared to severe (76 ± 17%) and moderate (81±15%) cases (p < .001). A total of 159/278 patients had a decreased DLCO (<80%), of whom the DLCO improved after 6 months in 45% (71/159). However the DLCO did not normalize in the majority (89%) of the cases (63 ± 10% vs 68±10%; p < .001). At 3 months, compared to critical cases, moderate cases scored lower on SF-36 domain “general health” (p < .05); both moderate and severe cases scored lower on the domain of “health change” (p < .05). At 6 months, there were no differences in SF-36 between the subgroups. Compared to 3 months, in all groups “physical functioning” improved; in contrast all groups scored significantly lower on “non-physical” SF-36 domains. CONCLUSION: Three months after COVID-19 pneumonia, DLCO was still decreased in the more severely affected patients, with an incomplete recovery after 6 months. At 3 months QoL was impaired. At 6 months, while “physical functioning” improved, a decrease in “non-physical” QoL was observed but did not differ between the moderate and severely affected patients. |
format | Online Article Text |
id | pubmed-9659768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-96597682022-11-15 Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months de Roos, Marlise P Siegerink, Sebastiaan Dijkstra, Nynke G Broekman, Birit FP Brinkman, Kees Jonkman, Nini H Bresser, Paul Chron Respir Dis Original Paper OBJECTIVES: A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients. METHODS: COVID-19 pneumonia survivors (n = 317) were categorized into non-hospitalized “moderate” cases (n = 59), hospitalized “severe” cases (n = 180) and ICU-admitted “critical” cases (n = 39). We studied DLCO and QoL (Short Form SF-36 health survey) 3 and 6 months after discharge. Data were analyzed using (repeated measures) ANOVA, Kruskal-Wallis or Chi-square test (p < .05). RESULTS: At 3 months DLCO was decreased in 44% of moderate-, 56% of severe- and 82% of critical cases (p < .003). Mean DLCO in critical cases (64±14%) was lower compared to severe (76 ± 17%) and moderate (81±15%) cases (p < .001). A total of 159/278 patients had a decreased DLCO (<80%), of whom the DLCO improved after 6 months in 45% (71/159). However the DLCO did not normalize in the majority (89%) of the cases (63 ± 10% vs 68±10%; p < .001). At 3 months, compared to critical cases, moderate cases scored lower on SF-36 domain “general health” (p < .05); both moderate and severe cases scored lower on the domain of “health change” (p < .05). At 6 months, there were no differences in SF-36 between the subgroups. Compared to 3 months, in all groups “physical functioning” improved; in contrast all groups scored significantly lower on “non-physical” SF-36 domains. CONCLUSION: Three months after COVID-19 pneumonia, DLCO was still decreased in the more severely affected patients, with an incomplete recovery after 6 months. At 3 months QoL was impaired. At 6 months, while “physical functioning” improved, a decrease in “non-physical” QoL was observed but did not differ between the moderate and severely affected patients. SAGE Publications 2022-11-11 /pmc/articles/PMC9659768/ /pubmed/36367295 http://dx.doi.org/10.1177/14799731221114271 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Paper de Roos, Marlise P Siegerink, Sebastiaan Dijkstra, Nynke G Broekman, Birit FP Brinkman, Kees Jonkman, Nini H Bresser, Paul Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months |
title | Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months |
title_full | Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months |
title_fullStr | Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months |
title_full_unstemmed | Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months |
title_short | Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months |
title_sort | pulmonary function and quality of life in a prospective cohort of (non-) hospitalized covid-19 pneumonia survivors up to six months |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659768/ https://www.ncbi.nlm.nih.gov/pubmed/36367295 http://dx.doi.org/10.1177/14799731221114271 |
work_keys_str_mv | AT deroosmarlisep pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths AT siegerinksebastiaan pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths AT dijkstranynkeg pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths AT broekmanbiritfp pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths AT brinkmankees pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths AT jonkmanninih pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths AT bresserpaul pulmonaryfunctionandqualityoflifeinaprospectivecohortofnonhospitalizedcovid19pneumoniasurvivorsuptosixmonths |