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Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients
BACKGROUND: Vitamin D (Vit-D) is a necessary ingredient for human growth and its deficiency may increase the risk of cancer and its recurrence. The main purpose of this research was to assess the levels of Vit-D in children with recurrence of malignancy and compare it with new cases of malignancy an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659826/ https://www.ncbi.nlm.nih.gov/pubmed/36420327 http://dx.doi.org/10.22088/cjim.13.4.735 |
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author | Reisi, Nahid Mirzaei, Azar Moafi, Alireza Raeissi, Pouran Naghdhassani, Maryam |
author_facet | Reisi, Nahid Mirzaei, Azar Moafi, Alireza Raeissi, Pouran Naghdhassani, Maryam |
author_sort | Reisi, Nahid |
collection | PubMed |
description | BACKGROUND: Vitamin D (Vit-D) is a necessary ingredient for human growth and its deficiency may increase the risk of cancer and its recurrence. The main purpose of this research was to assess the levels of Vit-D in children with recurrence of malignancy and compare it with new cases of malignancy and the control group. METHODS: The status of 25(OH) Vit-D was determined utilizing the HPLC method in 47 patients with recurrence of malignancy (group A), 50 children with new malignancy (group B) and 49 normal healthy siblings of the two groups as a control (group C). RESULTS: Vit-D was low (<30 ng/ml) in the 92% of patients with recurrence of malignancy, which was a significant difference compared to groups B (60%) and C (45%). Vit-D insufficiency (10-30 ng/dl) in group A was also higher than the other two groups. The mean levels of Vit-D in patients with recurrence were significantly lower than the new cases and controls. Low Vit-D (<30 ng/ml) in group A in both male and female, and also in all ages (<6 and ≥ 6 years) was higher than groups B and C. Also, low Vit-D in terms of the type of malignancy in group A was higher than group B only in leukemic patients while this was not different for non-leukemic patients in these two groups. CONCLUSION: Results of this study showed an increased prevalence of low Vit-D in children with recurrence of malignancies. Therefore, it may increase the risk of recurrence of malignancies in children. |
format | Online Article Text |
id | pubmed-9659826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-96598262022-11-22 Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients Reisi, Nahid Mirzaei, Azar Moafi, Alireza Raeissi, Pouran Naghdhassani, Maryam Caspian J Intern Med Original Article BACKGROUND: Vitamin D (Vit-D) is a necessary ingredient for human growth and its deficiency may increase the risk of cancer and its recurrence. The main purpose of this research was to assess the levels of Vit-D in children with recurrence of malignancy and compare it with new cases of malignancy and the control group. METHODS: The status of 25(OH) Vit-D was determined utilizing the HPLC method in 47 patients with recurrence of malignancy (group A), 50 children with new malignancy (group B) and 49 normal healthy siblings of the two groups as a control (group C). RESULTS: Vit-D was low (<30 ng/ml) in the 92% of patients with recurrence of malignancy, which was a significant difference compared to groups B (60%) and C (45%). Vit-D insufficiency (10-30 ng/dl) in group A was also higher than the other two groups. The mean levels of Vit-D in patients with recurrence were significantly lower than the new cases and controls. Low Vit-D (<30 ng/ml) in group A in both male and female, and also in all ages (<6 and ≥ 6 years) was higher than groups B and C. Also, low Vit-D in terms of the type of malignancy in group A was higher than group B only in leukemic patients while this was not different for non-leukemic patients in these two groups. CONCLUSION: Results of this study showed an increased prevalence of low Vit-D in children with recurrence of malignancies. Therefore, it may increase the risk of recurrence of malignancies in children. Babol University of Medical Sciences 2022 /pmc/articles/PMC9659826/ /pubmed/36420327 http://dx.doi.org/10.22088/cjim.13.4.735 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Reisi, Nahid Mirzaei, Azar Moafi, Alireza Raeissi, Pouran Naghdhassani, Maryam Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
title | Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
title_full | Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
title_fullStr | Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
title_full_unstemmed | Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
title_short | Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
title_sort | vitamin d abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659826/ https://www.ncbi.nlm.nih.gov/pubmed/36420327 http://dx.doi.org/10.22088/cjim.13.4.735 |
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