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Drug interactions in elderly (Amirkola Health and Ageing Project)

BACKGROUND: Due to physiological changes and co-existing chronic diseases, the elderly has to take various drugs with different mechanisms that may increase the risk of drug interactions and side effects of medications. This study was performed to evaluate the profile of drug interactions of Amirkol...

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Autores principales: Fath Tabar, Zahra, Moghadamnia, Ahmad Reza, Bijani, Ali, Hosseini, Seyed Reza, Moghadamnia, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659841/
https://www.ncbi.nlm.nih.gov/pubmed/36420341
http://dx.doi.org/10.22088/cjim.13.4.786
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author Fath Tabar, Zahra
Moghadamnia, Ahmad Reza
Bijani, Ali
Hosseini, Seyed Reza
Moghadamnia, Ali Akbar
author_facet Fath Tabar, Zahra
Moghadamnia, Ahmad Reza
Bijani, Ali
Hosseini, Seyed Reza
Moghadamnia, Ali Akbar
author_sort Fath Tabar, Zahra
collection PubMed
description BACKGROUND: Due to physiological changes and co-existing chronic diseases, the elderly has to take various drugs with different mechanisms that may increase the risk of drug interactions and side effects of medications. This study was performed to evaluate the profile of drug interactions of Amirkola elderly patients. METHODS: This cross-sectional descriptive-analytical study is part of the Amirkola Health and Ageing Project (AHAP) which was done during 2012-2013 (Amirkola, Babol, Iran). Initial data collection was done on 1616 persons of ages 60 and older by observing their prescribed drugs and those prepared by self-medications. RESULTS: Drug interactions were detected in 31.7% (95% CI; 29.41, 33.95) of the drug prescriptions. This included 28% of mild, 63.3% of moderate and 8.7% of severe drug interactions. Cardiovascular drugs (64.4%) were the most frequent drugs that induced drug-interactions. According on Beer criteria 2015, 39.97% of the elderly medications were identified as “inappropriate medication”. NSAIDs had the highest prevalence of inappropriate drugs. There was a significant relationship between female gender, having underlying disease, living alone, having insurance, and polypharmacy with obtained drug interaction results (p<0.05). CONCLUSION: The findings of the present study indicate considerable drug interactions among the elderly in Amirkola, which highlights the need for careful prescribing and using of drugs in the elderly.
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spelling pubmed-96598412022-11-22 Drug interactions in elderly (Amirkola Health and Ageing Project) Fath Tabar, Zahra Moghadamnia, Ahmad Reza Bijani, Ali Hosseini, Seyed Reza Moghadamnia, Ali Akbar Caspian J Intern Med Original Article BACKGROUND: Due to physiological changes and co-existing chronic diseases, the elderly has to take various drugs with different mechanisms that may increase the risk of drug interactions and side effects of medications. This study was performed to evaluate the profile of drug interactions of Amirkola elderly patients. METHODS: This cross-sectional descriptive-analytical study is part of the Amirkola Health and Ageing Project (AHAP) which was done during 2012-2013 (Amirkola, Babol, Iran). Initial data collection was done on 1616 persons of ages 60 and older by observing their prescribed drugs and those prepared by self-medications. RESULTS: Drug interactions were detected in 31.7% (95% CI; 29.41, 33.95) of the drug prescriptions. This included 28% of mild, 63.3% of moderate and 8.7% of severe drug interactions. Cardiovascular drugs (64.4%) were the most frequent drugs that induced drug-interactions. According on Beer criteria 2015, 39.97% of the elderly medications were identified as “inappropriate medication”. NSAIDs had the highest prevalence of inappropriate drugs. There was a significant relationship between female gender, having underlying disease, living alone, having insurance, and polypharmacy with obtained drug interaction results (p<0.05). CONCLUSION: The findings of the present study indicate considerable drug interactions among the elderly in Amirkola, which highlights the need for careful prescribing and using of drugs in the elderly. Babol University of Medical Sciences 2022 /pmc/articles/PMC9659841/ /pubmed/36420341 http://dx.doi.org/10.22088/cjim.13.4.786 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fath Tabar, Zahra
Moghadamnia, Ahmad Reza
Bijani, Ali
Hosseini, Seyed Reza
Moghadamnia, Ali Akbar
Drug interactions in elderly (Amirkola Health and Ageing Project)
title Drug interactions in elderly (Amirkola Health and Ageing Project)
title_full Drug interactions in elderly (Amirkola Health and Ageing Project)
title_fullStr Drug interactions in elderly (Amirkola Health and Ageing Project)
title_full_unstemmed Drug interactions in elderly (Amirkola Health and Ageing Project)
title_short Drug interactions in elderly (Amirkola Health and Ageing Project)
title_sort drug interactions in elderly (amirkola health and ageing project)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659841/
https://www.ncbi.nlm.nih.gov/pubmed/36420341
http://dx.doi.org/10.22088/cjim.13.4.786
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