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Noncoding RNA-mediated regulation of pyroptotic cell death in cancer

Pyroptosis is a newly discovered form of programmed cell death, which is manifested by DNA fragmentation, cell swelling, cell membrane rupture and leakage of cell contents. Previous studies have demonstrated that pyroptosis is tightly associated with the initiation and development of various cancers...

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Autores principales: Wang, Man, Zhang, Yuan, Chang, Wenguang, Zhang, Lei, Syrigos, Konstantinos N., Li, Peifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659888/
https://www.ncbi.nlm.nih.gov/pubmed/36387211
http://dx.doi.org/10.3389/fonc.2022.1015587
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author Wang, Man
Zhang, Yuan
Chang, Wenguang
Zhang, Lei
Syrigos, Konstantinos N.
Li, Peifeng
author_facet Wang, Man
Zhang, Yuan
Chang, Wenguang
Zhang, Lei
Syrigos, Konstantinos N.
Li, Peifeng
author_sort Wang, Man
collection PubMed
description Pyroptosis is a newly discovered form of programmed cell death, which is manifested by DNA fragmentation, cell swelling, cell membrane rupture and leakage of cell contents. Previous studies have demonstrated that pyroptosis is tightly associated with the initiation and development of various cancers, whereas the molecular mechanisms underlying pyroptosis remain obscure. Noncoding RNAs (ncRNAs) are a type of heterogeneous transcripts that are broadly expressed in mammalian cells. Owing to their potency of regulating gene expression, ncRNAs play essential roles in physiological and pathological processes. NcRNAs are increasingly acknowledged as important regulators of the pyroptosis process. Importantly, the crosstalk between ncRNAs and pyroptosis affects various hallmarks of cancer, including cell growth, survival, metastasis and therapeutic resistance. The study of the involvement of pyroptosis-associated ncRNAs in cancer pathobiology has become a hot area in recent years, while there are limited reviews on this topic. Herein, we provide an overview of the complicated roles of ncRNAs, mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), in modulating pyroptosis, with a focus on the underlying mechanisms of the ncRNA-pyroptosis axis in cancer pathogenesis. Finally, we discuss the potential applications and challenges of exploiting pyroptosis-regulating ncRNAs as molecular biomarkers and therapeutic targets in cancer.
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spelling pubmed-96598882022-11-15 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer Wang, Man Zhang, Yuan Chang, Wenguang Zhang, Lei Syrigos, Konstantinos N. Li, Peifeng Front Oncol Oncology Pyroptosis is a newly discovered form of programmed cell death, which is manifested by DNA fragmentation, cell swelling, cell membrane rupture and leakage of cell contents. Previous studies have demonstrated that pyroptosis is tightly associated with the initiation and development of various cancers, whereas the molecular mechanisms underlying pyroptosis remain obscure. Noncoding RNAs (ncRNAs) are a type of heterogeneous transcripts that are broadly expressed in mammalian cells. Owing to their potency of regulating gene expression, ncRNAs play essential roles in physiological and pathological processes. NcRNAs are increasingly acknowledged as important regulators of the pyroptosis process. Importantly, the crosstalk between ncRNAs and pyroptosis affects various hallmarks of cancer, including cell growth, survival, metastasis and therapeutic resistance. The study of the involvement of pyroptosis-associated ncRNAs in cancer pathobiology has become a hot area in recent years, while there are limited reviews on this topic. Herein, we provide an overview of the complicated roles of ncRNAs, mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), in modulating pyroptosis, with a focus on the underlying mechanisms of the ncRNA-pyroptosis axis in cancer pathogenesis. Finally, we discuss the potential applications and challenges of exploiting pyroptosis-regulating ncRNAs as molecular biomarkers and therapeutic targets in cancer. Frontiers Media S.A. 2022-10-31 /pmc/articles/PMC9659888/ /pubmed/36387211 http://dx.doi.org/10.3389/fonc.2022.1015587 Text en Copyright © 2022 Wang, Zhang, Chang, Zhang, Syrigos and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Man
Zhang, Yuan
Chang, Wenguang
Zhang, Lei
Syrigos, Konstantinos N.
Li, Peifeng
Noncoding RNA-mediated regulation of pyroptotic cell death in cancer
title Noncoding RNA-mediated regulation of pyroptotic cell death in cancer
title_full Noncoding RNA-mediated regulation of pyroptotic cell death in cancer
title_fullStr Noncoding RNA-mediated regulation of pyroptotic cell death in cancer
title_full_unstemmed Noncoding RNA-mediated regulation of pyroptotic cell death in cancer
title_short Noncoding RNA-mediated regulation of pyroptotic cell death in cancer
title_sort noncoding rna-mediated regulation of pyroptotic cell death in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659888/
https://www.ncbi.nlm.nih.gov/pubmed/36387211
http://dx.doi.org/10.3389/fonc.2022.1015587
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