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Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”

PURPOSE OF REVIEW: Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. RECENT FINDINGS: Herein, we review key aspects of protract...

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Autores principales: Dioverti, Veronica, Salto-Alejandre, Sonsoles, Haidar, Ghady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660019/
https://www.ncbi.nlm.nih.gov/pubmed/36407883
http://dx.doi.org/10.1007/s40472-022-00385-y
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author Dioverti, Veronica
Salto-Alejandre, Sonsoles
Haidar, Ghady
author_facet Dioverti, Veronica
Salto-Alejandre, Sonsoles
Haidar, Ghady
author_sort Dioverti, Veronica
collection PubMed
description PURPOSE OF REVIEW: Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. RECENT FINDINGS: Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. SUMMARY: Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.
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spelling pubmed-96600192022-11-14 Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters” Dioverti, Veronica Salto-Alejandre, Sonsoles Haidar, Ghady Curr Transplant Rep COVID-19 and Transplantation (RK Avery and DL Segev, Section Editors) PURPOSE OF REVIEW: Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. RECENT FINDINGS: Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. SUMMARY: Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research. Springer International Publishing 2022-11-12 2022 /pmc/articles/PMC9660019/ /pubmed/36407883 http://dx.doi.org/10.1007/s40472-022-00385-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle COVID-19 and Transplantation (RK Avery and DL Segev, Section Editors)
Dioverti, Veronica
Salto-Alejandre, Sonsoles
Haidar, Ghady
Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
title Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
title_full Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
title_fullStr Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
title_full_unstemmed Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
title_short Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”
title_sort immunocompromised patients with protracted covid-19: a review of “long persisters”
topic COVID-19 and Transplantation (RK Avery and DL Segev, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660019/
https://www.ncbi.nlm.nih.gov/pubmed/36407883
http://dx.doi.org/10.1007/s40472-022-00385-y
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