No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

BACKGROUND: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. OBJECTIVE: Thus, we examined the ass...

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Detalles Bibliográficos
Autores principales: Kim, Yong-Chan, Won, Sae-Young, Jeong, Byung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660098/
https://www.ncbi.nlm.nih.gov/pubmed/36408482
http://dx.doi.org/10.1007/s13273-022-00318-x
Descripción
Sumario:BACKGROUND: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. OBJECTIVE: Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. RESULTS: We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. CONCLUSIONS: To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.

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