Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction

Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects...

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Detalles Bibliográficos
Autores principales: Dentone, Chiara, Fenoglio, Daniela, Parodi, Alessia, Altosole, Tiziana, Di Biagio, Antonio, Bozzano, Federica, Nasi, Giorgia, Vena, Antonio, Fabbi, Marina, Ferrera, Francesca, Bruzzone, Bianca, Giacomini, Mauro, Giacobbe, Daniele Roberto, Pelosi, Paolo, De Maria, Andrea, Bassetti, Matteo, De Palma, Raffaele, Filaci, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660192/
https://www.ncbi.nlm.nih.gov/pubmed/36372857
http://dx.doi.org/10.1007/s10238-022-00927-9
Descripción
Sumario:Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C–C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10238-022-00927-9.

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