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Characterization of meningiomas with synthetic imaging

INTRODUCTION: Synthetic magnetic resonance imaging (SyMRI) is a novel quantitative and qualitative technique that permits the reconstruction of multiple image contrasts and quantitative maps from a single scan, thereby providing quantitative information and reducing scan times. The purpose of this s...

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Autores principales: Ludovichetti, Riccardo, Delattre, Bénédicte, Boto, José, LaGrange, Daniela, Meling, Torstein, Vargas, Maria Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660428/
https://www.ncbi.nlm.nih.gov/pubmed/36225121
http://dx.doi.org/10.1002/brb3.2769
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author Ludovichetti, Riccardo
Delattre, Bénédicte
Boto, José
LaGrange, Daniela
Meling, Torstein
Vargas, Maria Isabel
author_facet Ludovichetti, Riccardo
Delattre, Bénédicte
Boto, José
LaGrange, Daniela
Meling, Torstein
Vargas, Maria Isabel
author_sort Ludovichetti, Riccardo
collection PubMed
description INTRODUCTION: Synthetic magnetic resonance imaging (SyMRI) is a novel quantitative and qualitative technique that permits the reconstruction of multiple image contrasts and quantitative maps from a single scan, thereby providing quantitative information and reducing scan times. The purpose of this study is to characterize intracranial meningiomas using SyMRI. METHODS: The study included 35 patients with meningiomas (6 males, 29 females; mean age 61 ± 17 years; range 21–90 years). Using 3T MR scanners, SyMRI was performed in addition to conventional FSET2, FLAIR, DWI, T1, and T1 with gadolinium. SyMRI software was used to generate T1, T2, and PD quantitative maps. Osirix MD was used to measure quantitative values of T1, T2, and PD using a ROI. RESULTS: We analyzed 42 meningiomas, 8 of which were associated with edema, and 5 contained calcifications. Mean relaxivity values of meningiomas on synthetic T1, T2, and PD maps at 3T MRI were 1382.6 ± 391.7 ms, 95.6 ± 36.5 ms, and 89.1 ± 9.7 pu, respectively. Signal intensities in terms of T1, T2, and PD did not differ significantly between meningiomas with and without edema (p = .994, p = .356, and p = .221, respectively), nor between meningiomas containing and not containing calcifications (p = .840, p = .710, and p = .455, respectively). Values of T1 and T2 measured in meningiomas and the normal‐appearing white matter approximated reference values found in the literature with other quantitative methods. CONCLUSION: The presented method offers a novel approach to characterize meningiomas through their relaxation parameters measured with a SyMRI sequence.
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spelling pubmed-96604282022-11-14 Characterization of meningiomas with synthetic imaging Ludovichetti, Riccardo Delattre, Bénédicte Boto, José LaGrange, Daniela Meling, Torstein Vargas, Maria Isabel Brain Behav Original Articles INTRODUCTION: Synthetic magnetic resonance imaging (SyMRI) is a novel quantitative and qualitative technique that permits the reconstruction of multiple image contrasts and quantitative maps from a single scan, thereby providing quantitative information and reducing scan times. The purpose of this study is to characterize intracranial meningiomas using SyMRI. METHODS: The study included 35 patients with meningiomas (6 males, 29 females; mean age 61 ± 17 years; range 21–90 years). Using 3T MR scanners, SyMRI was performed in addition to conventional FSET2, FLAIR, DWI, T1, and T1 with gadolinium. SyMRI software was used to generate T1, T2, and PD quantitative maps. Osirix MD was used to measure quantitative values of T1, T2, and PD using a ROI. RESULTS: We analyzed 42 meningiomas, 8 of which were associated with edema, and 5 contained calcifications. Mean relaxivity values of meningiomas on synthetic T1, T2, and PD maps at 3T MRI were 1382.6 ± 391.7 ms, 95.6 ± 36.5 ms, and 89.1 ± 9.7 pu, respectively. Signal intensities in terms of T1, T2, and PD did not differ significantly between meningiomas with and without edema (p = .994, p = .356, and p = .221, respectively), nor between meningiomas containing and not containing calcifications (p = .840, p = .710, and p = .455, respectively). Values of T1 and T2 measured in meningiomas and the normal‐appearing white matter approximated reference values found in the literature with other quantitative methods. CONCLUSION: The presented method offers a novel approach to characterize meningiomas through their relaxation parameters measured with a SyMRI sequence. John Wiley and Sons Inc. 2022-10-12 /pmc/articles/PMC9660428/ /pubmed/36225121 http://dx.doi.org/10.1002/brb3.2769 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ludovichetti, Riccardo
Delattre, Bénédicte
Boto, José
LaGrange, Daniela
Meling, Torstein
Vargas, Maria Isabel
Characterization of meningiomas with synthetic imaging
title Characterization of meningiomas with synthetic imaging
title_full Characterization of meningiomas with synthetic imaging
title_fullStr Characterization of meningiomas with synthetic imaging
title_full_unstemmed Characterization of meningiomas with synthetic imaging
title_short Characterization of meningiomas with synthetic imaging
title_sort characterization of meningiomas with synthetic imaging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660428/
https://www.ncbi.nlm.nih.gov/pubmed/36225121
http://dx.doi.org/10.1002/brb3.2769
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