An Alzheimer’s Disease Mechanism Based on Early Pathology, Anatomy, Vascular-Induced Flow, and Migration of Maximum Flow Stress Energy Location with Increasing Vascular Disease

This paper suggests a chemical mechanism for the earliest stages of Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) flow stresses provide the energy needed to induce molecular conformation changes leading to AD by initiating amyloid-β (Aβ) and tau aggregation. Shear and extensional flow stresses...

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Detalles Bibliográficos
Autores principales: Trumbore, Conrad N., Raghunandan, Aditya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661328/
https://www.ncbi.nlm.nih.gov/pubmed/36155517
http://dx.doi.org/10.3233/JAD-220622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661328/
https://www.ncbi.nlm.nih.gov/pubmed/36155517
http://dx.doi.org/10.3233/JAD-220622

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