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A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice

Multiple system atrophy (MSA) is a sporadic and progressive neurodegenerative disorder with a complex differential diagnosis. A range of disorders— also of nondegenerative etiology— can mimic MSA, expanding its differential diagnosis. Both misdiagnosis and diagnostic delays are relatively common in...

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Autores principales: Kauppila, Linda Azevedo, Ten Holter, Susanne E.M., van de Warrenburg, Bart, Bloem, Bastiaan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661336/
https://www.ncbi.nlm.nih.gov/pubmed/36057832
http://dx.doi.org/10.3233/JPD-223392
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author Kauppila, Linda Azevedo
Ten Holter, Susanne E.M.
van de Warrenburg, Bart
Bloem, Bastiaan R.
author_facet Kauppila, Linda Azevedo
Ten Holter, Susanne E.M.
van de Warrenburg, Bart
Bloem, Bastiaan R.
author_sort Kauppila, Linda Azevedo
collection PubMed
description Multiple system atrophy (MSA) is a sporadic and progressive neurodegenerative disorder with a complex differential diagnosis. A range of disorders— also of nondegenerative etiology— can mimic MSA, expanding its differential diagnosis. Both misdiagnosis and diagnostic delays are relatively common in clinical practice. A correct diagnosis is vital for daily clinical practice, in order to facilitate proper counselling and to timely install therapies in treatable disorders that mimic MSA. A correct diagnosis is also essential for including properly classified individuals into research studies that aim to better understand the pathophysiology of MSA, to develop specific biomarkers or to evaluate novel symptomatic or disease-modifying therapies. Here, we offer some practical guidance to support the diagnostic process, by highlighting conditions that may be considered as MSA lookalikes, by emphasizing some key clinical aspects of these mimics, and by discussing several useful ancillary diagnostic tests.
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spelling pubmed-96613362022-11-28 A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice Kauppila, Linda Azevedo Ten Holter, Susanne E.M. van de Warrenburg, Bart Bloem, Bastiaan R. J Parkinsons Dis Review Multiple system atrophy (MSA) is a sporadic and progressive neurodegenerative disorder with a complex differential diagnosis. A range of disorders— also of nondegenerative etiology— can mimic MSA, expanding its differential diagnosis. Both misdiagnosis and diagnostic delays are relatively common in clinical practice. A correct diagnosis is vital for daily clinical practice, in order to facilitate proper counselling and to timely install therapies in treatable disorders that mimic MSA. A correct diagnosis is also essential for including properly classified individuals into research studies that aim to better understand the pathophysiology of MSA, to develop specific biomarkers or to evaluate novel symptomatic or disease-modifying therapies. Here, we offer some practical guidance to support the diagnostic process, by highlighting conditions that may be considered as MSA lookalikes, by emphasizing some key clinical aspects of these mimics, and by discussing several useful ancillary diagnostic tests. IOS Press 2022-10-14 /pmc/articles/PMC9661336/ /pubmed/36057832 http://dx.doi.org/10.3233/JPD-223392 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kauppila, Linda Azevedo
Ten Holter, Susanne E.M.
van de Warrenburg, Bart
Bloem, Bastiaan R.
A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice
title A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice
title_full A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice
title_fullStr A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice
title_full_unstemmed A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice
title_short A Guide for the Differential Diagnosis of Multiple System Atrophy in Clinical Practice
title_sort guide for the differential diagnosis of multiple system atrophy in clinical practice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661336/
https://www.ncbi.nlm.nih.gov/pubmed/36057832
http://dx.doi.org/10.3233/JPD-223392
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