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Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling
The term “neural plasticity” was first used to describe non-pathological changes in neuronal structure. Today, it is generally accepted that the brain is a dynamic system whose morphology and function is influenced by a variety of factors including stress, diet, and exercise. Neural plasticity invol...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661351/ https://www.ncbi.nlm.nih.gov/pubmed/36448042 http://dx.doi.org/10.3233/BPL-220140 |
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author | Fakhoury, Marc Eid, Fady El Ahmad, Perla Khoury, Reine Mezher, Amar El Masri, Diala Haddad, Zena Zoghbi, Yara Ghayad, Litsa Maria Sleiman, Sama F. Stephan, Joseph S. |
author_facet | Fakhoury, Marc Eid, Fady El Ahmad, Perla Khoury, Reine Mezher, Amar El Masri, Diala Haddad, Zena Zoghbi, Yara Ghayad, Litsa Maria Sleiman, Sama F. Stephan, Joseph S. |
author_sort | Fakhoury, Marc |
collection | PubMed |
description | The term “neural plasticity” was first used to describe non-pathological changes in neuronal structure. Today, it is generally accepted that the brain is a dynamic system whose morphology and function is influenced by a variety of factors including stress, diet, and exercise. Neural plasticity involves learning and memory, the synthesis of new neurons, the repair of damaged connections, and several other compensatory mechanisms. It is altered in neurodegenerative disorders and following damage to the central or peripheral nervous system. Understanding the mechanisms that regulate neural plasticity in both healthy and diseased states is of significant importance to promote cognition and develop rehabilitation techniques for functional recovery after injury. In this minireview, we will discuss the mechanisms by which environmental factors promote neural plasticity with a focus on exercise- and diet-induced factors. We will highlight the known circulatory factors that are released in response to exercise and discuss how all factors activate pathways that converge in part on the activation of BDNF signaling. We propose to harness the therapeutic potential of exercise by using BDNF as a biomarker to identify novel endogenous factors that promote neural plasticity. We also discuss the importance of combining exercise factors with dietary factors to develop a lifestyle pill for patients afflicted by CNS disorders. |
format | Online Article Text |
id | pubmed-9661351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96613512022-11-28 Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling Fakhoury, Marc Eid, Fady El Ahmad, Perla Khoury, Reine Mezher, Amar El Masri, Diala Haddad, Zena Zoghbi, Yara Ghayad, Litsa Maria Sleiman, Sama F. Stephan, Joseph S. Brain Plast Review The term “neural plasticity” was first used to describe non-pathological changes in neuronal structure. Today, it is generally accepted that the brain is a dynamic system whose morphology and function is influenced by a variety of factors including stress, diet, and exercise. Neural plasticity involves learning and memory, the synthesis of new neurons, the repair of damaged connections, and several other compensatory mechanisms. It is altered in neurodegenerative disorders and following damage to the central or peripheral nervous system. Understanding the mechanisms that regulate neural plasticity in both healthy and diseased states is of significant importance to promote cognition and develop rehabilitation techniques for functional recovery after injury. In this minireview, we will discuss the mechanisms by which environmental factors promote neural plasticity with a focus on exercise- and diet-induced factors. We will highlight the known circulatory factors that are released in response to exercise and discuss how all factors activate pathways that converge in part on the activation of BDNF signaling. We propose to harness the therapeutic potential of exercise by using BDNF as a biomarker to identify novel endogenous factors that promote neural plasticity. We also discuss the importance of combining exercise factors with dietary factors to develop a lifestyle pill for patients afflicted by CNS disorders. IOS Press 2022-10-21 /pmc/articles/PMC9661351/ /pubmed/36448042 http://dx.doi.org/10.3233/BPL-220140 Text en © 2022 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Fakhoury, Marc Eid, Fady El Ahmad, Perla Khoury, Reine Mezher, Amar El Masri, Diala Haddad, Zena Zoghbi, Yara Ghayad, Litsa Maria Sleiman, Sama F. Stephan, Joseph S. Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling |
title | Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling |
title_full | Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling |
title_fullStr | Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling |
title_full_unstemmed | Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling |
title_short | Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling |
title_sort | exercise and dietary factors mediate neural plasticity through modulation of bdnf signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661351/ https://www.ncbi.nlm.nih.gov/pubmed/36448042 http://dx.doi.org/10.3233/BPL-220140 |
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