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Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium

Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological...

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Autores principales: Oskarsson, Viktor, Eliasson, Mats, Salomaa, Veikko, Reinikainen, Jaakko, Männistö, Satu, Palmieri, Luigi, Donfrancesco, Chiara, Sans, Susana, Costanzo, Simona, de Gaetano, Giovanni, Iacoviello, Licia, Veronesi, Giovanni, Ferrario, Marco M., Padro, Teresa, Thorand, Barbara, Huth, Cornelia, Zeller, Tanja, Blankenberg, Stefan, Anderson, Annie S., Tunstall-Pedoe, Hugh, Kuulasmaa, Kari, Söderberg, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661368/
https://www.ncbi.nlm.nih.gov/pubmed/34933700
http://dx.doi.org/10.1017/S0007114521005080
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author Oskarsson, Viktor
Eliasson, Mats
Salomaa, Veikko
Reinikainen, Jaakko
Männistö, Satu
Palmieri, Luigi
Donfrancesco, Chiara
Sans, Susana
Costanzo, Simona
de Gaetano, Giovanni
Iacoviello, Licia
Veronesi, Giovanni
Ferrario, Marco M.
Padro, Teresa
Thorand, Barbara
Huth, Cornelia
Zeller, Tanja
Blankenberg, Stefan
Anderson, Annie S.
Tunstall-Pedoe, Hugh
Kuulasmaa, Kari
Söderberg, Stefan
author_facet Oskarsson, Viktor
Eliasson, Mats
Salomaa, Veikko
Reinikainen, Jaakko
Männistö, Satu
Palmieri, Luigi
Donfrancesco, Chiara
Sans, Susana
Costanzo, Simona
de Gaetano, Giovanni
Iacoviello, Licia
Veronesi, Giovanni
Ferrario, Marco M.
Padro, Teresa
Thorand, Barbara
Huth, Cornelia
Zeller, Tanja
Blankenberg, Stefan
Anderson, Annie S.
Tunstall-Pedoe, Hugh
Kuulasmaa, Kari
Söderberg, Stefan
author_sort Oskarsson, Viktor
collection PubMed
description Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48·9 %; median age 50·8 years; examination period 1984–2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65·6–63·8°N), Germany (at 48·4°N), Finland (at 65·0–60·2°N), Italy (at 45·6–41·5°N), Scotland (at 58·2–55·1°N) and Spain (at 41·5°N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3·03, 3·28, 5·41, 6·54 and 9·28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0·001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.
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spelling pubmed-96613682022-11-23 Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium Oskarsson, Viktor Eliasson, Mats Salomaa, Veikko Reinikainen, Jaakko Männistö, Satu Palmieri, Luigi Donfrancesco, Chiara Sans, Susana Costanzo, Simona de Gaetano, Giovanni Iacoviello, Licia Veronesi, Giovanni Ferrario, Marco M. Padro, Teresa Thorand, Barbara Huth, Cornelia Zeller, Tanja Blankenberg, Stefan Anderson, Annie S. Tunstall-Pedoe, Hugh Kuulasmaa, Kari Söderberg, Stefan Br J Nutr Research Article Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48·9 %; median age 50·8 years; examination period 1984–2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65·6–63·8°N), Germany (at 48·4°N), Finland (at 65·0–60·2°N), Italy (at 45·6–41·5°N), Scotland (at 58·2–55·1°N) and Spain (at 41·5°N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3·03, 3·28, 5·41, 6·54 and 9·28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0·001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans. Cambridge University Press 2022-12-14 2021-12-22 /pmc/articles/PMC9661368/ /pubmed/34933700 http://dx.doi.org/10.1017/S0007114521005080 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited
spellingShingle Research Article
Oskarsson, Viktor
Eliasson, Mats
Salomaa, Veikko
Reinikainen, Jaakko
Männistö, Satu
Palmieri, Luigi
Donfrancesco, Chiara
Sans, Susana
Costanzo, Simona
de Gaetano, Giovanni
Iacoviello, Licia
Veronesi, Giovanni
Ferrario, Marco M.
Padro, Teresa
Thorand, Barbara
Huth, Cornelia
Zeller, Tanja
Blankenberg, Stefan
Anderson, Annie S.
Tunstall-Pedoe, Hugh
Kuulasmaa, Kari
Söderberg, Stefan
Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
title Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
title_full Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
title_fullStr Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
title_full_unstemmed Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
title_short Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
title_sort influence of geographical latitude on vitamin d status: cross-sectional results from the biomarcare consortium
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661368/
https://www.ncbi.nlm.nih.gov/pubmed/34933700
http://dx.doi.org/10.1017/S0007114521005080
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